Barrea Luigi, Tarantino Giovanni, Somma Carolina Di, Muscogiuri Giovanna, Macchia Paolo Emidio, Falco Andrea, Colao Annamaria, Savastano Silvia
I.O.S. & COLEMAN Srl, Acerra, 80011 Naples, Italy.
Dipartimento di Medicina Clinica e Chirurgia, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.
Oxid Med Cell Longev. 2017;2017:6101254. doi: 10.1155/2017/6101254. Epub 2017 Jun 15.
This study was aimed at evaluating sirtuin 4 (Sirt4) levels in obese individuals, in relation to their adherence to the Mediterranean diet (MD), a healthy dietary pattern characterized by high antioxidant capacity, and markers of visceral fat storage.
SUBJECTS/METHODS: Forty-three obese patients (44% males; BMI: 36.7-58.8 kg/m) were consecutively included. PREvención con DIeta MEDiterránea (PREDIMED) and the 7-day food records were used to assess the adherence to MD and dietary pattern, respectively. Visceral adiposity index (VAI) was calculated. Sirt4 levels were detected by ELISA method.
The majority of the obese participants (62.8%) had an average adherence to MD. Compared with average adherers, low adherers had higher BMI, energy intake, and percentage of energy from lipids, mainly saturated fat and polyunsaturated fatty acids (PUFA), and lower Sirt4 levels. After adjusting for BMI, Sirt4 levels remained negatively correlated with VAI. After adjusting for total energy intake, Sirt4 levels remained negatively associated with PREDIMED and consumption of n-3 PUFA, vitamins C and E. The threshold value of PREDIMED predicting the lowest decrease in Sirt4 levels was found at a score of 6.
Less reduced Sirt4 levels in obese patients adhering to MD suggest a further aspect of the antioxidant advantage of MD.
本研究旨在评估肥胖个体中沉默调节蛋白4（Sirt4）的水平，及其与地中海饮食（MD）的依从性、内脏脂肪储存标志物的关系。MD是一种具有高抗氧化能力的健康饮食模式。
受试者/方法：连续纳入43例肥胖患者（男性占44%；BMI：36.7 - 58.8 kg/m²）。分别采用地中海饮食预防（PREDIMED）和7天食物记录来评估对MD的依从性和饮食模式。计算内脏肥胖指数（VAI）。采用ELISA法检测Sirt4水平。
大多数肥胖参与者（62.8%）对MD的依从性为中等。与中等依从者相比，低依从者的BMI、能量摄入量以及来自脂质（主要是饱和脂肪和多不饱和脂肪酸[PUFA]）的能量百分比更高，而Sirt4水平更低。在调整BMI后，Sirt4水平仍与VAI呈负相关。在调整总能量摄入量后，Sirt4水平仍与PREDIMED以及n - 3 PUFA、维生素C和E的摄入量呈负相关。发现PREDIMED预测Sirt4水平最低下降的阈值分数为6分。
遵循MD的肥胖患者中Sirt4水平降低较少，这表明MD抗氧化优势的另一个方面。
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