Suppr超能文献

年龄与减肥手术的手术时间和代谢风险严重程度相关,会使单核细胞趋化蛋白-1(MCP-1)水平升高。

Age increases MCP-1 level in association with bariatric surgery operating time and metabolic risk severity.

作者信息

Malin S K, Kaplan J L, Meng L, Garmey J C, Kirby J L, Taylor A M, Hallowell P T, McNamara C A

机构信息

Department of Kinesiology University of Virginia Charlottesville USA.

Divison of Endocrinology and Metabolism University of Virginia Charlottesville USA.

出版信息

Obes Sci Pract. 2017 Apr 26;3(2):193-200. doi: 10.1002/osp4.105. eCollection 2017 Jun.

Abstract

OBJECTIVE

Assess the role of inflammation on operating time in younger vs. older bariatric surgery patients.

METHODS

Fifty-five younger (F: 46, Age: 34.9 ± 4.0 years, body mass index [BMI]: 48.2 ± 1.0 kg m) and 48 older (F: 34, Age: 57.0 ± 5.1 years, BMI: 46.8 ± 1.0 kg m) adults were studied prior to surgery. Blood pressure, glycaemic control (fasting glucose/insulin, HbA), lipids (high-density lipoprotein and triglycerides) and inflammation (monocyte chemoattractant protein-1 [MCP-1]) were assessed. Metabolic risk severity -scores were calculated from clinical outcomes. Omental adipose biopsies were collected at surgery for MCP-1 protein analysis. Operating time was used to characterize surgical difficulty.

RESULTS

Older vs. younger adults had higher HbA ( = 0.03). There was no difference in BMI, lipids, metabolic risk severity or insulin between groups, but operating time was longer in older vs. younger individuals ( = 0.04). Circulating MCP-1 was also elevated in older vs. younger adults ( = 0.04) independent of HbA, although this was not explained by omental fat. Nevertheless, serum MCP-1 was associated with increased metabolic risk severity ( = 0.27,  = 0.01). In addition, operating time was linked to HbA ( = 0.30,  = 0.01) and omental MCP-1 protein ( = 0.31,  < 0.01).

CONCLUSIONS

MCP-1 is associated with longer operating time and increased metabolic risk severity in older bariatric patients independent of glycaemic control. Pre-operative treatment of inflammation may be required to enhance surgery effectiveness.

摘要

目的

评估炎症在年轻与老年肥胖症手术患者手术时间方面所起的作用。

方法

对55名年轻成年人(女性46名,年龄34.9±4.0岁,体重指数[BMI]:48.2±1.0kg/m²)和48名老年成年人(女性34名,年龄57.0±5.1岁,BMI:46.8±1.0kg/m²)在手术前进行研究。评估血压、血糖控制情况(空腹血糖/胰岛素、糖化血红蛋白)、血脂(高密度脂蛋白和甘油三酯)以及炎症指标(单核细胞趋化蛋白-1[MCP-1])。根据临床结果计算代谢风险严重程度评分。在手术时采集网膜脂肪活检样本用于MCP-1蛋白分析。用手术时间来表征手术难度。

结果

老年成年人的糖化血红蛋白高于年轻成年人(P=0.03)。两组在BMI、血脂、代谢风险严重程度或胰岛素方面无差异,但老年个体的手术时间比年轻个体更长(P=0.04)。与年轻成年人相比,老年成年人循环中的MCP-1也升高(P=0.04),且与糖化血红蛋白无关,尽管网膜脂肪并不能解释这一现象。然而,血清MCP-1与代谢风险严重程度增加相关(P=0.27,r=0.01)。此外,手术时间与糖化血红蛋白(P=0.30,r=0.01)和网膜MCP-1蛋白相关(P=0.31,P<0.01)。

结论

在老年肥胖症患者中,MCP-1与更长的手术时间及代谢风险严重程度增加相关,且与血糖控制无关。可能需要在术前进行炎症治疗以提高手术效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9273/5527505/81991dc32ce3/OSP4-3-193-g001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验