Wang Nelson, Phan Steven, Tian David H, Yan Tristan D, Phan Kevin
Sydney Medical School, University of Sydney, Sydney, Australia.
Collaborative Research (CORE) Group, Macquarie University, Sydney, Australia.
Ann Cardiothorac Surg. 2017 May;6(3):194-203. doi: 10.21037/acs.2017.05.05.
Up to 20% of patients have pre-discharge residual moderate to severe tricuspid regurgitation (TR) after tricuspid repair. Reoperations for recurrent TR carry high mortality rates, which emphasizes the importance of identifying the optimal technique for the surgical management of TR. The present study is a systematic review and meta-analysis that aims to compare short and long term survival and freedom from TR of flexible band ring versus rigid ring for annuloplasty of TR.
We conducted a systematic review and meta-analysis of comparative studies to evaluate these procedures. A systematic search of the literature was performed from six electronic databases. Pooled meta-analysis was conducted using odds ratio (OR) and weighted mean difference (WMD).
The rates of in-hospital mortality were not different between the two groups, with cumulative rates of 6.9% for flexible band and 7.3% for rigid ring (OR: 0.92; 95% CI: 0.49-1.71). Rates of stroke were also similar with 1.7% of flexible band and 1.3% of rigid rings suffering a perioperative stroke (OR: 1.29; 95% CI: 0.74-2.23). Rigid ring had significantly better freedom from grade ≥2 TR at 5 years (OR: 0.44; 95% CI: 0.20-0.99) and overall (P=0.005). There was no significant difference in overall rates of reoperation (P=0.232) and survival (P=0.086) between flexible band and rigid ring.
Both rigid ring and flexible band offer acceptable outcomes for the treatment of TR. Compared to flexible band, rates of TR are stable after rigid ring annuloplasty and long term freedom from TR are superior for rigid ring devices. Large prospective randomized trials are required in order to validate these findings and assess for improvements in patient survival.
高达20%的患者在三尖瓣修复术后出院时仍有中度至重度三尖瓣反流(TR)。复发性TR再次手术的死亡率很高,这凸显了确定TR手术管理最佳技术的重要性。本研究是一项系统评价和荟萃分析,旨在比较柔性带环与刚性环用于TR瓣环成形术的短期和长期生存率及无TR情况。
我们对比较研究进行了系统评价和荟萃分析,以评估这些手术。从六个电子数据库中对文献进行了系统检索。使用比值比(OR)和加权平均差(WMD)进行汇总荟萃分析。
两组的住院死亡率无差异,柔性带环的累积死亡率为6.9%,刚性环为7.3%(OR:0.92;95%置信区间:0.49 - 1.71)。中风发生率也相似,柔性带环有1.7%、刚性环有1.3%在围手术期发生中风(OR:1.29;95%置信区间:0.74 - 2.23)。刚性环在5年时(OR:0.44;95%置信区间:0.20 - 0.99)及总体上(P = 0.005)无≥2级TR的情况明显更好。柔性带环和刚性环在再次手术总体发生率(P = 0.232)和生存率(P = 0.086)方面无显著差异。
刚性环和柔性带环在治疗TR方面均有可接受的结果。与柔性带环相比,刚性环瓣环成形术后TR发生率稳定,刚性环装置长期无TR情况更优。需要进行大型前瞻性随机试验以验证这些发现并评估患者生存率的改善情况。