Gyimah J E, Panigrahy B
Avian Dis. 1985 Oct-Dec;29(4):1078-83.
Immunogenicity of an oil-emulsified Escherichia coli (serotype O1) pili vaccine was evaluated in chickens. Chickens were vaccinated with 116 micrograms or 29 micrograms of pili protein and challenged with the homologous E. coli via the posterior thoracic air sac. Unvaccinated chickens were challenged to serve as positive controls or left unchallenged to serve as negative controls. Vaccinated chickens were protected against challenge because they suffered low or no mortality; had mild gross lesions in air sacs, pericardial sacs, and livers, and the scored values were significantly (P less than or equal to 0.05) lower than those in the positive controls; and eliminated E. coli from tissues more efficiently than the positive controls.
对一种油乳化大肠杆菌（血清型O1）菌毛疫苗在鸡体内的免疫原性进行了评估。用116微克或29微克菌毛蛋白对鸡进行免疫接种，并通过后胸气囊用同源大肠杆菌进行攻毒。未接种疫苗的鸡进行攻毒作为阳性对照，或不进行攻毒作为阴性对照。接种疫苗的鸡受到了攻毒保护，因为它们的死亡率低或无死亡；气囊、心包囊和肝脏有轻度肉眼可见病变，且评分值显著（P≤0.05）低于阳性对照；并且比阳性对照更有效地从组织中清除大肠杆菌。
