Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, China.
Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Disease, Guangdong, China.
Neurol Sci. 2017 Oct;38(10):1753-1760. doi: 10.1007/s10072-017-3058-7. Epub 2017 Jul 13.
Ocular myasthenia gravis, an autoimmune disease, is characterized by extraocular muscle weakness. Myasthenia gravis is closely associated with the functional status of the thymus gland. The efficacy of thymectomy for non-thymomatous ocular myasthenia gravis remains controversial. Here, we present the first systematic review and meta-analysis of studies assessing the outcome of thymectomy in patients with non-thymomatous ocular myasthenia gravis and found that the pooled rate of complete stable remission was 0.5074 with considerable heterogeneity. Furthermore, subgroup analysis showed that the efficacy of thymectomy differed according to geographical location. Furthermore, thymectomy outcomes are better in children than they are in adults. Thymectomy clearly represents an effective treatment for patients with non-thymomatous ocular myasthenia gravis. However, more multicenter, randomized, controlled clinical trials are now required to confirm these conclusions.
眼肌型重症肌无力是一种自身免疫性疾病，其特征是眼外肌无力。重症肌无力与胸腺的功能状态密切相关。胸腺切除术治疗非胸腺瘤性眼肌型重症肌无力的疗效仍存在争议。在这里，我们首次对评估非胸腺瘤性眼肌型重症肌无力患者胸腺切除术结果的研究进行了系统评价和荟萃分析，发现完全稳定缓解的合并率为 0.5074，存在较大的异质性。此外，亚组分析显示，胸腺切除术的疗效因地理位置而异。此外，胸腺切除术在儿童中的疗效优于成人。胸腺切除术显然是治疗非胸腺瘤性眼肌型重症肌无力的有效方法。然而，现在需要更多的多中心、随机、对照临床试验来证实这些结论。
