Wang Jiaojian, Zuo Zhentao, Xie Sangma, Miao Yifan, Ma Yuanye, Zhao Xudong, Jiang Tianzi
Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 625014, China.
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Brain Topogr. 2018 Mar;31(2):161-173. doi: 10.1007/s10548-017-0576-9. Epub 2017 Jul 13.
The macaque model has been widely used to investigate the brain mechanisms of specific cognitive functions and psychiatric disorders. However, a detailed functional architecture map of the macaque cortex in vivo is still lacking. Here, we aimed to construct a new macaque cortex atlas based on its anatomical connectivity profiles using in vivo diffusion MRI. First, we defined the macaque cortical seed areas using the NeuroMaps atlas. Then, we applied the anatomical connectivity patterns-based parcellation approach to parcellate the macaque cortex into 80 subareas in each hemisphere, which were approximately symmetric between the two hemispheres. In each hemisphere, we identified 14 subareas in the frontal cortex, 9 subareas in the somatosensory cortex, 13 subareas in the parietal cortex, 16 subareas in the temporal cortex, 16 subareas in the occipital cortex, and 12 subareas in the limbic system. Finally, the graph-based network analyses of the anatomical network based on newly constructed macaque cortex atlas identified seven hub areas including bilateral ventral premotor cortex, bilateral superior parietal lobule, right medial precentral gyrus, and right precuneus. This newly constructed macaque cortex atlas may facilitate studies of the structure and functions of the macaque brain in the future.
猕猴模型已被广泛用于研究特定认知功能和精神疾病的脑机制。然而，猕猴皮层在体内的详细功能架构图谱仍然缺乏。在此，我们旨在利用体内扩散磁共振成像（MRI），基于其解剖连接图谱构建一个新的猕猴皮层图谱。首先，我们使用NeuroMaps图谱定义猕猴皮层种子区域。然后，我们应用基于解剖连接模式的分割方法，将猕猴皮层在每个半球分割为80个分区，两个半球之间大致对称。在每个半球中，我们在额叶皮层中识别出14个分区，在体感皮层中识别出9个分区，在顶叶皮层中识别出13个分区，在颞叶皮层中识别出16个分区，在枕叶皮层中识别出16个分区，在边缘系统中识别出12个分区。最后，基于新构建的猕猴皮层图谱对解剖网络进行基于图的网络分析，确定了七个枢纽区域，包括双侧腹侧运动前区皮层、双侧顶上小叶、右侧中央前回内侧和右侧楔前叶。这个新构建的猕猴皮层图谱可能会在未来促进对猕猴脑结构和功能的研究。
