Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense, Av. Universitária, 1105 Bairro Universitário, Criciúma, Santa Catarina, 88806-000, Brazil.
J Physiol Biochem. 2017 Nov;73(4):487-494. doi: 10.1007/s13105-017-0576-y. Epub 2017 Jul 14.
Transcriptional factors are easily susceptible to any stimuli, including exercise. Exercise can significantly influence PGC-1 α and AMPK-SIRT1 pathway, as it is involved in the regulation of energy metabolism and mitochondrial biogenesis. Exercise is a major energy deprivation process by which many of transcription factors get tuned positively. However, how transcription factors help to boost the antioxidant defense system at cellular level is elusive. It is well known that physical exercise can induce reactive oxygen species, but how these reactive oxygen species can help to regulate multiple transcription factors during exercise is an important area to be discussed yet. This review mainly focuses on interconnecting role of PGC-1 α and AMPK-SIRT1 pathway during exercise and how these proteins are getting tuned by reactive oxygen species in exercise condition.
转录因子很容易受到任何刺激的影响，包括运动。运动可以显著影响 PGC-1α 和 AMPK-SIRT1 通路，因为它参与调节能量代谢和线粒体生物发生。运动是一种主要的能量剥夺过程，许多转录因子在这个过程中得到正向调节。然而，转录因子如何帮助增强细胞水平的抗氧化防御系统还不清楚。众所周知，体育锻炼会引起活性氧，但这些活性氧如何在锻炼过程中帮助调节多种转录因子是一个有待讨论的重要领域。本综述主要关注运动过程中 PGC-1α 和 AMPK-SIRT1 通路的相互联系作用，以及这些蛋白质在运动条件下如何被活性氧调节。
