Anand Rahul, Sarode Gargi S, Sarode Sachin C, Reddy Mamatha, Unadkat Hemant V, Mushtaq Shazia, Deshmukh Revati, Choudhary Shakira, Gupta Nitin, Ganjre Anjali P, Patil Shankargouda
Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune, India.
National Dental Centre of Singapore, 5 Second Hospital Avenue, Singapore, Singapore.
J Investig Clin Dent. 2018 Feb;9(1). doi: 10.1111/jicd.12282. Epub 2017 Jul 14.
The aim of the present review was to systematically present the clinicopathological data of desmoplastic ameloblastoma (DA) from articles published in the literature. A comprehensive search of the databases (PubMed, Medline, SCOPUS, Web of Science, and Google Scholar) for published articles on DA was conducted. A total of 238 cases were identified and analyzed from 76 published papers. DA showed a slight male predilection (male: female=1.07:1) with a predominance in the fourth and fifth decades of life. Mandibular involvement (52.55%) was most commonly seen with a marked tendency for the anterior region (mandible: 40.9%, maxilla: 48.07%). The size of the lesion ranged from .5 cm to 20.4 cm, with the majority of cases measuring more than 3 cm in size (53.84%). Radiologically, most of the lesions presented mixed radiolucency and radiopacity (62%), and root resorption was observed in only seven cases. The majority of the lesions showed ill-defined margins upon radiographic examination (65.78%). Most of the cases were treated with resection (78.57%), and five of the 10 recurrent cases were treated by enucleation/curettage. DA is characterized by the unique presentation of clinicopathological parameters. It is not possible to comment on its aggressive/recurrent nature and best treatment modality due to inadequate follow-up data.
本综述的目的是系统地呈现文献中发表的有关促结缔组织增生性成釉细胞瘤（DA）的临床病理数据。我们对数据库（PubMed、Medline、SCOPUS、Web of Science和谷歌学术）进行了全面检索，以查找关于DA的已发表文章。从76篇已发表论文中确定并分析了总共238例病例。DA表现出轻微的男性偏好（男∶女 = 1.07∶1），在40至50岁人群中最为常见。下颌受累（52.55%）最为常见，且明显倾向于前部区域（下颌骨：40.9%，上颌骨：48.07%）。病变大小从0.5厘米至20.4厘米不等，大多数病例（53.84%）的大小超过3厘米。在放射学上，大多数病变表现为混合性透射线和不透射线（62%），仅7例观察到牙根吸收。在影像学检查中，大多数病变边界不清（65.78%）。大多数病例采用切除术治疗（78.57%），10例复发病例中有5例采用摘除/刮除术治疗。DA具有独特的临床病理参数表现。由于随访数据不足，无法对其侵袭性/复发性本质及最佳治疗方式进行评论。
