Dieguez C, Jordan V, Harris P, Foord S, Rodriguez-Arnao M D, Gomez-Pan A, Hall R, Scanlon M F
J Endocrinol. 1986 Apr;109(1):53-6. doi: 10.1677/joe.0.1090053.
In order to investigate whether the impaired GH secretion associated with hypothyroidism and hyperthyroidism is due to a hypothalamic or a pituitary disorder, we have studied plasma GH responses to GH-releasing factor (1-29) (GRF) in euthyroid, hypothyroid and hyperthyroid rats. Hypothyroid rats showed a significant (P less than 0.001) reduction in GH responses to GRF (5 micrograms/kg) at 5 min (350 +/- 35 vs 1950 +/- 260 micrograms/l), 10 min (366 +/- 66 vs 2320 +/- 270 micrograms/l) and 15 min after GRF injection (395 +/- 72 vs 1420 +/- 183 micrograms/l; mean +/- S.E.M.) compared with euthyroid rats. Hyperthyroid rats showed a significant (P less than 0.05) decrease in GH responses to 5 micrograms GRF/kg after 30 min (200 +/- 14 vs 325 +/- 35 micrograms/l) but not at other time-points, or after the administration of 1 microgram GRF/kg. These data indicate that in hypothyroidism and perhaps hyperthyroidism there is an alteration in the responsiveness of the somatotroph to GRF administration.
为了研究与甲状腺功能减退和甲状腺功能亢进相关的生长激素（GH）分泌受损是由于下丘脑还是垂体紊乱所致，我们研究了正常甲状腺、甲状腺功能减退和甲状腺功能亢进大鼠对生长激素释放因子（1 - 29）（GRF）的血浆GH反应。甲状腺功能减退大鼠在注射GRF（5微克/千克）后5分钟（350±35对1950±260微克/升）、10分钟（366±66对2320±270微克/升）和15分钟（395±72对1420±183微克/升；均值±标准误）时，对GRF的GH反应显著降低（P＜0.001），与正常甲状腺大鼠相比。甲状腺功能亢进大鼠在注射30分钟后对5微克GRF/千克的GH反应显著降低（P＜0.05）（200±14对325±35微克/升），但在其他时间点或注射1微克GRF/千克后无此现象。这些数据表明，在甲状腺功能减退以及可能在甲状腺功能亢进时，生长激素细胞对GRF给药的反应性发生了改变。
