Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States.
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States.
Cell Signal. 2018 Jan;41:17-24. doi: 10.1016/j.cellsig.2017.07.004. Epub 2017 Jul 12.
This review is provided in recognition of the extensive contributions of Dr. Robert J. Lefkowitz to the G protein-coupled receptor (GPCR) field and to celebrate his 75th birthday. Since one of the authors trained with Bob in the 80s, we provide a history of work done in the Lefkowitz lab during the 80s that focused on dissecting the mechanisms that regulate GPCR signaling, with a particular emphasis on the GPCR kinases (GRKs). In addition, we highlight structure/function characteristics of GRK interaction with GPCRs as well as a review of two recent reports that provide a molecular model for GRK-GPCR interaction. Finally, we offer our perspective on some future studies that we believe will drive this field.
这篇综述是为了表彰罗伯特·J·莱夫科维茨博士对 G 蛋白偶联受体 (GPCR) 领域的广泛贡献,并庆祝他的 75 岁生日。由于其中一位作者在 80 年代曾师从 Bob,因此我们提供了莱夫科维茨实验室在 80 年代期间开展的工作历史,重点是剖析调节 GPCR 信号转导的机制,特别强调 GPCR 激酶 (GRKs)。此外,我们还强调了 GRK 与 GPCR 相互作用的结构/功能特征,并回顾了最近的两项报告,这些报告提供了 GRK-GPCR 相互作用的分子模型。最后,我们对一些我们认为将推动这一领域发展的未来研究提出了看法。