是时候调整老年患者的利奈唑胺剂量了吗？ - Suppr

Is it time to revise linezolid dose in elderly patients?

作者信息

Tinelli Marco, Gervasoni Cristina, Piazza Manuela, Terzi Roberta, Cozzi Valeria, Maffezzini Elena, Cerri Chiara, Castoldi Simone, Baldelli Sara, Cattaneo Dario

机构信息

Division of Infectious and Tropical Diseases, Hospital of Lodi, Lodi, Italy.

Department of Infectious Diseases, L. Sacco University Hospital, Milan, Italy.

出版信息

Eur J Clin Pharmacol. 2017 Oct;73(10):1335-1336. doi: 10.1007/s00228-017-2303-6. Epub 2017 Jul 15.

DOI:10.1007/s00228-017-2303-6

PMID:28712044

Abstract

摘要

相似文献

Is it time to revise linezolid dose in elderly patients?

Eur J Clin Pharmacol. 2017 Oct;73(10):1335-1336. doi: 10.1007/s00228-017-2303-6. Epub 2017 Jul 15.

Linezolid underexposure in a patient co-treated with venlafaxine.

Eur J Clin Pharmacol. 2015 Oct;71(10):1285-6. doi: 10.1007/s00228-015-1922-z. Epub 2015 Aug 8.

Therapeutic drug management of linezolid: a missed opportunity for clinicians?

Int J Antimicrob Agents. 2016 Dec;48(6):728-731. doi: 10.1016/j.ijantimicag.2016.08.023. Epub 2016 Oct 12.

Pharmacokinetics and preliminary safety of high dose linezolid for the treatment of Gram-positive bacterial infections.

J Infect. 2015 Nov;71(5):604-7. doi: 10.1016/j.jinf.2015.06.007. Epub 2015 Jun 19.

Is it time to revise linezolid doses in peritoneal dialysis patients? A case series.

J Antimicrob Chemother. 2015 Oct;70(10):2918-20. doi: 10.1093/jac/dkv184. Epub 2015 Jul 3.

Risk factors associated with high linezolid trough plasma concentrations.

Expert Opin Pharmacother. 2016 Jun;17(9):1183-7. doi: 10.1080/14656566.2016.1182154. Epub 2016 May 11.

A 10-Year Experience of Therapeutic Drug Monitoring (TDM) of Linezolid in a Hospital-wide Population of Patients Receiving Conventional Dosing: Is there Enough Evidence for Suggesting TDM in the Majority of Patients?

Basic Clin Pharmacol Toxicol. 2017 Oct;121(4):303-308. doi: 10.1111/bcpt.12797. Epub 2017 Jun 19.

Pharmacokinetic/pharmacodynamic evaluation of linezolid for the treatment of staphylococcal infections in critically ill patients.

Int J Antimicrob Agents. 2016 Sep;48(3):259-64. doi: 10.1016/j.ijantimicag.2016.05.009. Epub 2016 Jul 5.

Linezolid Dosing in Patients With Liver Cirrhosis: Standard Dosing Risk Toxicity.

Ther Drug Monit. 2019 Dec;41(6):732-739. doi: 10.1097/FTD.0000000000000665.

Therapeutic drug monitoring of linezolid and exploring optimal regimens and a toxicity-related nomogram in elderly patients: a multicentre, prospective, non-interventional study.

J Antimicrob Chemother. 2024 Aug 1;79(8):1938-1950. doi: 10.1093/jac/dkae188.

引用本文的文献

Renal function affects the plasma concentration and hematological toxicity of linezolid in elderly patients: a propensity-matched cohort analysis.

BMC Geriatr. 2025 Aug 6;25(1):597. doi: 10.1186/s12877-025-06241-9.

Therapeutic Drug Monitoring of Linezolid in Drug-Resistant Tuberculosis Patients: Clinical Factors and Hematological Toxicities.

Infect Drug Resist. 2024 Jun 20;17:2531-2540. doi: 10.2147/IDR.S464429. eCollection 2024.

Therapeutic drug monitoring of linezolid and exploring optimal regimens and a toxicity-related nomogram in elderly patients: a multicentre, prospective, non-interventional study.

J Antimicrob Chemother. 2024 Aug 1;79(8):1938-1950. doi: 10.1093/jac/dkae188.

Population pharmacokinetics and dosage optimization of linezolid in Chinese older patients.

Eur J Clin Pharmacol. 2024 Sep;80(9):1295-1304. doi: 10.1007/s00228-024-03702-9. Epub 2024 May 27.

Linezolid dose adjustment according to therapeutic drug monitoring helps reach the goal concentration in severe patients, and the oldest seniors benefit more.

BMC Infect Dis. 2023 Nov 29;23(1):840. doi: 10.1186/s12879-023-08831-7.

Nomogram prediction model called "ADPLCP" for predicting linezolid-associated thrombocytopenia in elderly individuals.

J Intensive Med. 2023 Mar 4;3(3):268-274. doi: 10.1016/j.jointm.2022.12.003. eCollection 2023 Jul 31.

Linezolid-induced hematemesis, a rare and life-threatening adverse reaction. A case report of Karonga district in Malawi.

Oxf Med Case Reports. 2023 Mar 25;2023(3):omad020. doi: 10.1093/omcr/omad020. eCollection 2023 Mar.

A Review of Population Pharmacokinetic Analyses of Linezolid.

Clin Pharmacokinet. 2022 Jun;61(6):789-817. doi: 10.1007/s40262-022-01125-2. Epub 2022 Jun 14.

A possible interaction between linezolid and digoxin: A case report of therapeutic drug monitoring.

Saudi Pharm J. 2020 Nov;28(11):1408-1410. doi: 10.1016/j.jsps.2020.09.005. Epub 2020 Sep 14.

本文引用的文献

Adverse Drug Reaction-Related Hospitalizations in Elderly Australians: A Prospective Cross-Sectional Study in Two Tasmanian Hospitals.

Drug Saf. 2017 Jul;40(7):597-606. doi: 10.1007/s40264-017-0528-z.

Therapeutic drug management of linezolid: a missed opportunity for clinicians?

Int J Antimicrob Agents. 2016 Dec;48(6):728-731. doi: 10.1016/j.ijantimicag.2016.08.023. Epub 2016 Oct 12.

Drug monitoring and individual dose optimization of antimicrobial drugs: oxazolidinones.

Expert Opin Drug Metab Toxicol. 2016 May;12(5):533-44. doi: 10.1517/17425255.2016.1166204. Epub 2016 Mar 28.

Analysis of thrombocytopenic effects and population pharmacokinetics of linezolid: a dosage strategy according to the trough concentration target and renal function in adult patients.

Int J Antimicrob Agents. 2014 Sep;44(3):242-7. doi: 10.1016/j.ijantimicag.2014.05.010. Epub 2014 Jun 24.

Linezolid plasma concentrations and occurrence of drug-related haematological toxicity in patients with gram-positive infections.

Int J Antimicrob Agents. 2013 Jun;41(6):586-9. doi: 10.1016/j.ijantimicag.2013.02.020. Epub 2013 Apr 4.

Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis.

Antimicrob Agents Chemother. 2010 Nov;54(11):4605-10. doi: 10.1128/AAC.00177-10. Epub 2010 Aug 23.

Hospitalizations because of adverse drug reactions in elderly patients admitted through the emergency department: a prospective survey.

Drugs Aging. 2009;26(6):475-82. doi: 10.2165/00002512-200926060-00004.

Population pharmacokinetic analysis of linezolid in patients with infectious disease: application to lower body weight and elderly patients.

J Clin Pharmacol. 2009 Sep;49(9):1071-8. doi: 10.1177/0091270009337947. Epub 2009 Jun 23.

Pharmacokinetics and drug metabolism in the elderly.

Drug Metab Rev. 2009;41(2):67-76. doi: 10.1080/03602530902722679.

Is inappropriate medication use a major cause of adverse drug reactions in the elderly?

Br J Clin Pharmacol. 2007 Feb;63(2):177-86. doi: 10.1111/j.1365-2125.2006.02831.x. Epub 2006 Dec 7.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Is it time to revise linezolid dose in elderly patients?

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献