Connor M J
Life Sci. 1986 May 19;38(20):1807-12. doi: 10.1016/0024-3205(86)90134-7.
Retinoids are potent inducers of epidermal hyperplasia in vivo. Epidermal transglutaminase activity and stratum corneum turnover were examined in all-trans-retinoic acid and arotinoid ethyl ester treated hairless mice, to evaluate the possible contribution of decreased epidermal cell loss to the induction of hyperplasia by retinoids. Stratum corneum turnover was enhanced, and the absolute amounts (activity/cm2), but not the specific activities, of soluble and particulate transglutaminase increased following retinoid treatment. Since epidermal differentiation was enhanced after retinoid treatment, the hyperplastic response is due to increased cell formation and not decreased cell loss.
维甲酸在体内是表皮增生的强效诱导剂。在全反式维甲酸和芳维甲酸乙酯处理的无毛小鼠中检测了表皮转谷氨酰胺酶活性和角质层更新情况，以评估表皮细胞损失减少对维甲酸诱导增生的可能作用。维甲酸处理后角质层更新加快，可溶性和颗粒性转谷氨酰胺酶的绝对量（活性/平方厘米）增加，但比活性未增加。由于维甲酸处理后表皮分化增强，增生反应是由于细胞形成增加而非细胞损失减少所致。
