Gonec Tomas, Stranik Josef, Pesko Matus, Kos Jiri, Oravec Michal, Kralova Katarina, Jampilek Josef
Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1, 61242 Brno, Czech Republic.
Department of Environmental Ecology, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 84215 Bratislava, Slovakia.
Molecules. 2017 Jul 17;22(7):1199. doi: 10.3390/molecules22071199.
Eight 1-[(2-chlorophenyl)carbamoyl]naphthalen-2-yl alkylcarbamates and eight 1-[(2-nitrophenyl)carbamoyl]naphthalen-2-yl alkylcarbamates were tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach ( L.) chloroplasts. The PET-inhibiting activity of the compounds was relatively low; the corresponding IC values ranged from 0.05 to 0.664 mmol/L; and the highest activity within the series of compounds was observed for 1-[(2-chlorophenyl)-carbamoyl]naphthalen-2-yl propylcarbamate. It has been proven that the compounds are PET-inhibitors in photosystem II. Despite rather low PET-inhibiting activities, primary structure-activity trends can be discussed.
测试了8种1-[(2-氯苯基)氨基甲酰基]萘-2-基烷基氨基甲酸酯和8种1-[(2-硝基苯基)氨基甲酰基]萘-2-基烷基氨基甲酸酯对菠菜叶绿体光合电子传递（PET）抑制作用的相关活性。这些化合物的PET抑制活性相对较低；相应的IC值范围为0.05至0.664 mmol/L；在该系列化合物中，1-[(2-氯苯基)氨基甲酰基]萘-2-基丙基氨基甲酸酯的活性最高。已证明这些化合物是光系统II中的PET抑制剂。尽管PET抑制活性相当低，但仍可讨论其一级结构-活性趋势。
