Morgan Patrick, Nissi Mikko J, Hughes John, Mortazavi Shabnam, Ellermann Jutta
1 Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN, USA.
2 Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.
Cartilage. 2018 Jul;9(3):237-240. doi: 10.1177/1947603517719316. Epub 2017 Jul 17.
Objectives The purpose of this study was to validate T2* mapping as an objective, noninvasive method for the prediction of acetabular cartilage damage. Methods This is the second step in the validation of T2*. In a previous study, we established a quantitative predictive model for identifying and grading acetabular cartilage damage. In this study, the model was applied to a second cohort of 27 consecutive hips to validate the model. A clinical 3.0-T imaging protocol with T2* mapping was used. Acetabular regions of interest (ROI) were identified on magnetic resonance and graded using the previously established model. Each ROI was then graded in a blinded fashion by arthroscopy. Accurate surgical location of ROIs was facilitated with a 2-dimensional map projection of the acetabulum. A total of 459 ROIs were studied. Results When T2* mapping and arthroscopic assessment were compared, 82% of ROIs were within 1 Beck group (of a total 6 possible) and 32% of ROIs were classified identically. Disease prediction based on receiver operating characteristic curve analysis demonstrated a sensitivity of 0.713 and a specificity of 0.804. Model stability evaluation required no significant changes to the predictive model produced in the initial study. Conclusions These results validate that T2* mapping provides statistically comparable information regarding acetabular cartilage when compared to arthroscopy. In contrast to arthroscopy, T2* mapping is quantitative, noninvasive, and can be used in follow-up. Unlike research quantitative magnetic resonance protocols, T2* takes little time and does not require a contrast agent. This may facilitate its use in the clinical sphere.
目的 本研究旨在验证T2成像作为预测髋臼软骨损伤的一种客观、非侵入性方法。方法 这是T2成像验证的第二步。在之前的一项研究中，我们建立了一个用于识别和分级髋臼软骨损伤的定量预测模型。在本研究中，该模型应用于连续27例髋关节的第二个队列以验证该模型。采用具有T2成像的临床3.0-T成像方案。在磁共振上识别髋臼感兴趣区（ROI），并使用先前建立的模型进行分级。然后由关节镜检查人员以盲法对每个ROI进行分级。髋臼的二维地图投影有助于ROI的准确手术定位。共研究了459个ROI。结果 比较T2成像和关节镜评估时，82%的ROI在1个Beck组内（总共6个可能组），32%的ROI分类相同。基于受试者工作特征曲线分析的疾病预测显示敏感性为0.713，特异性为0.804。模型稳定性评估表明初始研究中产生的预测模型无需显著改变。结论 这些结果验证了与关节镜检查相比，T2成像在髋臼软骨方面提供了具有统计学可比性的信息。与关节镜检查不同，T2成像是定量的、非侵入性的，可用于随访。与研究性定量磁共振检查方案不同，T2*成像耗时少且不需要造影剂。这可能便于其在临床领域的应用。
