Laboratory of Plant Biotechnology, Faculty of Sciences of Sfax, 3038 Sfax, Tunisia.
Laboratory of Enzyme Engineering and Microbiology, National School of Engineering of Sfax, University of Sfax, P.O. 1173-3038, Sfax, Tunisia.
Int J Biol Macromol. 2017 Dec;105(Pt 1):598-607. doi: 10.1016/j.ijbiomac.2017.07.079. Epub 2017 Jul 14.
Diabetes is a serious condition that is linked to the development of oxidative stress. In the context of enhancing the biodiversity of Tunisia's flora, this study aimed to evaluate the effect of Sargussum vulgare sulfated polysaccharide (SVSP) on hyperglycemia and diabetes complications in the alloxan-induced diabetic rats. Our results showed a disturbance of carbohydrate, lipid, hematological and histopathological parameters, an increase in the α-amylase enzyme activity and damage to the pancreatic, hepatic and renal tissues in rats rendered diabetic by alloxan. In contrast, treatment with SVSP resulted in a correction of fasting and postprandial blood glucose and HbA1c through inhibition of pancreatic α-amylase. We also noticed an improvement in hemogram parameters and an attenuation of the pancreatic oxidative stress markers as well as histological protections. On the other hand, the administration of SVSP to diabetic rats caused, besides the correction of glycemic and lipid parameters, a good defense against hepatotoxicity and nephrotoxicity of diabetes as well as good antioxidant status and histological protections.
糖尿病是一种严重的疾病，与氧化应激的发展有关。在提高突尼斯植物生物多样性的背景下，本研究旨在评估马尾藻硫酸多糖（SVSP）对丙烯醛诱导的糖尿病大鼠高血糖和糖尿病并发症的影响。我们的结果表明，碳水化合物、脂质、血液学和组织病理学参数受到干扰，α-淀粉酶酶活性增加，胰腺、肝脏和肾脏组织受损，用丙烯醛使大鼠患上糖尿病。相比之下，SVSP 的治疗通过抑制胰腺 α-淀粉酶，纠正空腹和餐后血糖以及 HbA1c。我们还注意到血液学参数的改善以及胰腺氧化应激标志物的衰减和组织学保护。另一方面，SVSP 给药除了纠正血糖和脂质参数外，还能很好地抵抗糖尿病引起的肝毒性和肾毒性，以及良好的抗氧化状态和组织学保护。
