Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Cold Spring Harb Perspect Biol. 2018 Jun 1;10(6):a028811. doi: 10.1101/cshperspect.a028811.
Immune enhancement of dengue disease continues to be a concern for those with incomplete immunity in endemic areas. Advanced testing and follow-up of a newly available live attenuated dengue vaccine has recently shown the ability of vaccination to predispose some recipients for a severe outcome on subsequent infection. To improve safety, recommendations have been made to restrict use of the vaccine to those who are likely to have had prior exposure to dengue virus (DENV). Researchers continue to investigate dengue immunity and seek evidence that dengue vaccines can be safely administered to all populations needing protection.
在地方性流行地区,对不完全免疫人群而言,登革热疾病的免疫增强作用仍然令人担忧。最近,对新出现的减毒活疫苗的更先进的检测和随访表明,接种疫苗使一些受种者在随后的感染中更容易出现严重后果。为了提高安全性,建议将疫苗的使用限制在那些可能以前接触过登革热病毒(DENV)的人群。研究人员继续研究登革热免疫,并寻求证据表明,登革热疫苗可以安全地用于所有需要保护的人群。