Hayashi Y, Saito H, Saito S, Yanagawa T, Yoshida H, Yura Y, Sato M
Am J Pathol. 1986 May;123(2):250-5.
The presence of somatostatin (SRIF) in the neoplastic epithelial cells of certain Warthin's tumors arising in the human parotid gland was found immunohistochemically, whereas the other parotid gland tumors, such as pleomorphic adenoma, oxyphilic adenoma, mucoepidermoid tumor, adenocarcinoma, and adenoid cystic carcinoma, did not show positive immunoreactivity for SRIF. The SRIF-positive Warthin's tumor had dense core granules immunoreactive with anti-SRIF serum. Moreover, a comparatively high concentration of immunoreactive SRIF was detected by radioimmunoassay in an SRIF-positive Warthin's tumor, although the other tumors also contained low levels of immunoreactive SRIF.
免疫组织化学研究发现，在人类腮腺发生的某些沃辛瘤的肿瘤上皮细胞中存在生长抑素（SRIF），而其他腮腺肿瘤，如多形性腺瘤、嗜酸性腺瘤、黏液表皮样癌、腺癌和腺样囊性癌，对SRIF没有阳性免疫反应。SRIF阳性的沃辛瘤有与抗SRIF血清发生免疫反应的致密核心颗粒。此外，通过放射免疫测定法在SRIF阳性的沃辛瘤中检测到相对较高浓度的免疫反应性SRIF，尽管其他肿瘤也含有低水平的免疫反应性SRIF。
