Traoré Fousseyni, Eshun Francis, Togo Boubacar, Yao Jean Jacques Atteby, Lukamba Mbuli Robert
and , Centre Hospitalier Universitaire (CHU) Gabriel-Touré, Bamako, Mali; , Phoenix Children's Hospital, Phoenix, AZ; , CHU of Treichville, Abidjan, Côte d'Ivoire; and , University Clinics of Lubumbashi, Lubumbashi, Democratic Republic of Congo.
J Glob Oncol. 2016 Mar 2;2(4):169-173. doi: 10.1200/JGO.2015.001214. eCollection 2016 Aug.
Neuroblastoma is a sympathoadrenal lineage neural crest-derived tumor. It is the third most common childhood malignancy in the Western world. Studies from the United States show that black patients with neuroblastoma have a greater proportion of high-risk neuroblastoma with poorer prognosis compared with white patients. In Africa, there are few published data on the epidemiology and management of neuroblastoma. The primary aim of this study was to assess the diagnostic and therapeutic resources available for the management of neuroblastoma within the Franco-African Pediatric Oncology Group (GFAOP).
A survey was conducted in the pediatric oncology centers of the GFAOP. Participating GFAOP centers were Abidjan, Algiers, Bamako, Dakar, Lubumbashi, Lomé, Ouagadougou, Rabat, Tananarive Antananarivo, and Tunis. Questionnaires were sent out by e-mail to the principal investigators at each participating GFAOP center in December 2013.
Ten (62%) of 16 GFAOP centers responded to the questionnaire. Neuroblastoma represented only 3% to 5% of childhood cancers in the sub-Saharan African centers, with the exception of Antananarivo, where it represented 7.5%. In contrast, in the northern African centers of Tunis, Rabat, and Algiers, neuroblastoma accounted for 30%,10%, and 7% of childhood cancer, respectively. At initial diagnosis, 50% to 80% of patients had metastatic neuroblastoma in eight of 10 centers.
Based on this survey, neuroblastoma seems to be less common in sub-Saharan Africa. The proportion of patients with metastatic neuroblastoma seems to be higher than reported in Western countries.
神经母细胞瘤是一种起源于交感肾上腺谱系神经嵴的肿瘤。它是西方世界第三常见的儿童恶性肿瘤。美国的研究表明，与白人患者相比，患有神经母细胞瘤的黑人患者中高危神经母细胞瘤的比例更高，预后更差。在非洲，关于神经母细胞瘤的流行病学和治疗的公开数据很少。本研究的主要目的是评估法非儿科肿瘤学组（GFAOP）内可用于神经母细胞瘤治疗的诊断和治疗资源。
在GFAOP的儿科肿瘤中心进行了一项调查。参与的GFAOP中心有阿比让、阿尔及尔、巴马科、达喀尔、卢本巴希、洛美、瓦加杜古、拉巴特、塔那那利佛和突尼斯。2013年12月通过电子邮件向每个参与的GFAOP中心的主要研究者发送了问卷。
16个GFAOP中心中有10个（62%）回复了问卷。在撒哈拉以南非洲中心，神经母细胞瘤仅占儿童癌症的3%至5%，但塔那那利佛除外，那里占7.5%。相比之下，在突尼斯、拉巴特和阿尔及尔的北非中心，神经母细胞瘤分别占儿童癌症的30%、10%和7%。在10个中心中的8个中心，初诊时50%至80%的患者患有转移性神经母细胞瘤。
基于这项调查，神经母细胞瘤在撒哈拉以南非洲似乎不太常见。转移性神经母细胞瘤患者的比例似乎高于西方国家的报道。
