针对癌症中的激活转录因子5（ATF5）
Targeting ATF5 in Cancer.
作者信息
Angelastro James M
机构信息
Department of Molecular Biosciences, University of California, Davis School of Veterinary Medicine, Davis, CA 95616, USA.
出版信息
Trends Cancer. 2017 Jul;3(7):471-474. doi: 10.1016/j.trecan.2017.05.004. Epub 2017 Jun 13.
Abstract
The expression of activating transcription factor 5 (ATF5) correlates negatively with patient survival in different types of cancer. ATF5 is important for the survival and proliferation of cancer cells, and can be targeted to selectively trigger cancer cell apoptosis while sparing normal cells. Cell-penetrating peptides combined with a dominant negative ATF5 cargo have recently shown efficacy against brain, breast, melanoma, and prostate cancers.
摘要
激活转录因子5（ATF5）的表达与不同类型癌症患者的生存率呈负相关。ATF5对癌细胞的存活和增殖很重要，并且可以作为靶点来选择性地触发癌细胞凋亡，同时使正常细胞免受影响。细胞穿透肽与显性负性ATF5货物结合，最近已显示出对脑癌、乳腺癌、黑色素瘤和前列腺癌的疗效。
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