基于严重程度的女性痤疮患者血清睾酮和性激素结合球蛋白水平的相关性
Association Of Serum Testosterone And Sex Hormone Binding Globulin Levels In Females With Acne Based On Its Severity.
作者信息
Kiayani Asma Javed, Rehman Farid Ur
机构信息
Department of Dermatology, Foundation University Medical College, Islamabad, Pakistan.
出版信息
J Ayub Med Coll Abbottabad. 2016 Apr-Jun;28(2):357-359.
BACKGROUND
Androgens are involved in the development of acne. The aim of this study was to find out if there was an association of serum testosterone and sex hormone binding globulin (SHBG) in females with acne based on its severity.
METHODS
It was a cross sectional study, conducted in Dermatology unit of Fauji Foundation Hospital (FFH), Rawalpindi. Duration of study was eight months. Adult females with acne were enrolled in the study. Patients were categorized into minor, mild, moderate groups. Blood samples were taken for serum testosterone and SHBG.
RESULTS
Five hundred and thirty-one adult female were enrolled into the study. The mean age was 21.49±4.73 years. Acne was graded as minor in 78 (14.7%) cases, mild in 248 (46.7%) and moderate in 205 (38.6%). There was no statistically significant relationship between the levels of serum testosterone (p=0.776) and SHBG (p=0.711) with acne severity.
CONCLUSIONS
There was no association of serum testosterone and sex hormone binding globulin levels in females with acne based on its severity.
背景
雄激素与痤疮的发生有关。本研究的目的是基于痤疮严重程度，探究女性血清睾酮和性激素结合球蛋白（SHBG）之间是否存在关联。
方法
这是一项横断面研究，在拉瓦尔品第的法吉基金会医院（FFH）皮肤科进行。研究持续时间为八个月。纳入患有痤疮的成年女性。患者被分为轻度、中度、重度组。采集血样检测血清睾酮和SHBG。
结果
531名成年女性纳入研究。平均年龄为21.49±4.73岁。痤疮分级为轻度的有78例（14.7%），中度的有248例（46.7%），重度的有205例（38.6%）。血清睾酮水平（p = 0.776）和SHBG水平（p = 0.711）与痤疮严重程度之间无统计学显著关系。
结论
基于痤疮严重程度，女性血清睾酮和性激素结合球蛋白水平之间无关联。
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