Ocorr K A, Tabata M, Byrne J H
Brain Res. 1986 Apr 16;371(1):190-2. doi: 10.1016/0006-8993(86)90828-0.
Facilitation of synaptic connections between sensory neurons and motor neurons mediating the tail withdrawal reflex in Aplysia is produced by the modulatory effects of sensitizing stimuli. Facilitation can be mimicked by perfusing these neurons with serotonin (5-HT) in a semi-intact preparation. Consequently, 5-HT has been presumed to be acting as an agonist of the modulatory transmitter that mediates sensitizing input in vivo. While the 5-HT effects appear to be mediated by increased cyclic adenosine monophosphate (cAMP) levels in the sensory neurons, a critical issue that has not been examined is whether sensitizing stimuli also increase cAMP levels in these cells. We now report that such sensitizing stimuli delivered to the tail of a semi-intact preparation lead to elevation of cAMP levels in the tail sensory neurons.
在海兔中，介导尾部退缩反射的感觉神经元和运动神经元之间突触连接的易化是由致敏刺激的调节作用产生的。在半完整制备中，用5-羟色胺（5-HT）灌注这些神经元可模拟易化作用。因此，5-HT被认为是在体内介导致敏输入的调节性递质的激动剂。虽然5-HT的作用似乎是由感觉神经元中环状单磷酸腺苷（cAMP）水平的升高介导的，但一个尚未研究的关键问题是致敏刺激是否也会增加这些细胞中的cAMP水平。我们现在报告，给予半完整制备的海兔尾部的此类致敏刺激会导致尾部感觉神经元中cAMP水平升高。
