Dawbarn D, Zamir N, Waters C M, Hunt S P, Emson P C, Brownstein M J
Brain Res. 1986 Apr 30;372(1):155-8. doi: 10.1016/0006-8993(86)91469-1.
The contents of methionine-enkephalin-Arg-Gly-Leu, dynorphin A, dynorphin B and alpha-neoendorphin have been measured in both control and Huntington's disease brains obtained postmortem. All 4 peptides were significantly reduced in the caudate nucleus and putamen of Huntington's disease compared with the control group. No differences were observed in frontal cortex or hypothalamus. Immunocytochemistry showed a marked depletion of dynorphin-like immunoreactivity in Huntington's disease substantia nigra.
