Inokuchi A, Oomura Y
Brain Res Bull. 1986 Mar;16(3):429-33. doi: 10.1016/0361-9230(86)90068-7.
The effects of electrophoretically applied sleep-promoting substance (SPS) on neuronal activity of the preoptic area (POA) and SPS interactions with some neurotransmitters were examined in the rat. In the POA, 14% of the tested neurons were excited and 13% were inhibited by SPS. Neurons that were excited by SPS were also excited by glutamate (Glu). The excitatory effect of Glu was blocked or attenuated by concurrent application of SPS in 35% of the neurons, and this modulatory effect was long-lasting. A significant number of SPS responsive neurons were inhibited by noradrenaline (NA). This inhibitory effect was attenuated, blocked or reversed by concurrent application of SPS in 28% of the tested neurons. There was no relation between the effects of acetylcholine (ACh) alone and those of SPS alone. The effects of ACh were modified by concurrent SPS application in 21% of the neurons tested; the effect was either enhancement or blockade of the ACh excitation. Possible contribution of SPS in the hypothalamus to the regulation of sleep and wakefulness is discussed.
研究了电泳施加的促睡眠物质（SPS）对大鼠视前区（POA）神经元活动的影响以及SPS与某些神经递质的相互作用。在POA中，14%的受试神经元被SPS兴奋，13%被抑制。被SPS兴奋的神经元也被谷氨酸（Glu）兴奋。在35%的神经元中，同时施加SPS可阻断或减弱Glu的兴奋作用，且这种调节作用持久。大量对SPS有反应的神经元被去甲肾上腺素（NA）抑制。在28%的受试神经元中，同时施加SPS可减弱、阻断或逆转这种抑制作用。单独乙酰胆碱（ACh）的作用与单独SPS的作用之间没有关联。在21%的受试神经元中，同时施加SPS可改变ACh的作用；作用为增强或阻断ACh的兴奋作用。讨论了下丘脑SPS对睡眠和觉醒调节的可能作用。
