Rocci M L, Vlasses P H, Abrams W B
Cardiol Clin. 1986 May;4(2):213-25.
Age-related physiologic changes may significantly alter drug disposition and dynamics in the elderly. This is especially important for cardiovascular drugs, because they are used with such high frequency in the geriatric population. Alterations in the pharmacokinetics and pharmacodynamics of several drugs used to treat cardiovascular disease have been demonstrated in the elderly. Knowledge of these alterations may aid in more rational prescribing of cardiovascular drugs in the geriatric population.
与年龄相关的生理变化可能会显著改变老年人的药物处置和动力学。这对于心血管药物尤为重要,因为它们在老年人群中的使用频率很高。已证实老年人用于治疗心血管疾病的几种药物的药代动力学和药效学发生了改变。了解这些改变可能有助于更合理地为老年人群开具心血管药物处方。