Rochefort-Johnson S M, Willis D E, Addison R F
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1986;83(2):325-7. doi: 10.1016/0742-8413(86)90130-1.
1-[14C]Phenyl-1-(3,4-dimethyl)phenylethane ([14C]PXE), a labelled analogue of a component of some commercial PCB replacement materials, was cleared rapidly from plasma of the thorny skate, Raja radiata, after i.v. injection. A polyexponential fit to the clearance data yielded three linear components with half-lives of 7, 128 and 924 min. The metabolic clearance rate for the mean animal was approximately 41 X kg-1 X d-1. The main storage site for [14C]PXE was the liver, which contained about 40% of the injected dose. Approximately 25% of the injected radioactivity was recovered from the bile within 36 hr of injection in the form of polar metabolites, indicating rapid degradation of [14C]PXE.
1-[¹⁴C]苯基-1-(3,4-二甲基)苯乙烷([¹⁴C]PXE)是一些商用多氯联苯替代材料中一种成分的标记类似物，静脉注射后在棘鳐（Raja radiata）的血浆中迅速清除。对清除数据进行多指数拟合得到三个线性成分，半衰期分别为7、128和924分钟。平均每只动物的代谢清除率约为41×kg⁻¹×d⁻¹。[¹⁴C]PXE的主要储存部位是肝脏，其含有的放射性约为注射剂量的40%。在注射后36小时内，约25%的注射放射性以极性代谢物的形式从胆汁中回收，表明[¹⁴C]PXE迅速降解。
