新型β-肾上腺素能受体部分激动剂扎莫特罗对心绞痛患者的影响。

Effects of xamoterol a new beta-adrenoceptor partial agonist, in patients with angina pectoris.

作者信息

Barrios L, Geboers J, Piessens J H, de Geest H

出版信息

Eur J Clin Pharmacol. 1986;29(6):667-71. doi: 10.1007/BF00615956.

PMID:2872055

Abstract

The effects of xamoterol on exercise capacity have been evaluated in 10 patients with angina pectoris and well-preserved left ventricular function. Compared to placebo a single 200 mg dose of xamoterol produced a slight but insignificant increase in exercise capacity. At maximum work load, ST-T segment depression was reduced (3 mm and 2.19 mm after placebo and xamoterol, respectively; p less than 0.05). The changes paralleled an insignificant reduction in maximal heart rate and pressure-rate product. At rest, xamoterol increased the heart rate from 80 to 86 beats/min. Thus, at rest, when sympathetic tone is low, xamoterol acts as a beta-receptor agonist but during exercise, when sympathetic tone is high, xamoterol acts as an antagonist and reduces myocardial ischaemia.

摘要

已对10例心绞痛且左心室功能良好的患者评估了xamoterol对运动能力的影响。与安慰剂相比，单次服用200mg的xamoterol使运动能力有轻微但不显著的提高。在最大工作负荷下，ST-T段压低有所减轻（安慰剂和xamoterol后分别为3mm和2.19mm；p<0.05）。这些变化与最大心率和压力-心率乘积的不显著降低平行。静息时，xamoterol使心率从80次/分钟增加到86次/分钟。因此，在静息时，交感神经张力较低，xamoterol起β受体激动剂的作用，但在运动时，交感神经张力较高，xamoterol起拮抗剂的作用并减轻心肌缺血。