去除内皮后，α1和α2肾上腺素能受体激动剂诱导大鼠肠系膜动脉收缩。
Alpha 1- and alpha 2-adrenoceptor agonist-induced contraction in rat mesenteric artery upon removal of endothelium.
作者信息
White R E, Carrier G O
出版信息
Eur J Pharmacol. 1986 Apr 2;122(3):349-52. doi: 10.1016/0014-2999(86)90415-2.
Contractile response to norepinephrine, methoxamine and clonidine were determined in rat mesenteric arteries with and without an intact endothelium. Removal of the endothelial cell layer markedly enhanced the maximum contractile effect of norepinephrine (2.8 fold), methoxamine (4.0 fold) and clonidine (13.0 fold). Furthermore, there was a significant decrease in the EC50 values for these agonists. These findings indicate that both alpha 1- and alpha 2-adrenoceptor agonists can induce contraction of mesenteric arteries which is modulated by the endothelial cell layer.
在有完整内皮和无完整内皮的大鼠肠系膜动脉中测定了对去甲肾上腺素、甲氧明和可乐定的收缩反应。去除内皮细胞层显著增强了去甲肾上腺素（2.8倍）、甲氧明（4.0倍）和可乐定（13.0倍）的最大收缩效应。此外，这些激动剂的半数有效浓度（EC50）值显著降低。这些发现表明，α1和α2肾上腺素能受体激动剂均可诱导肠系膜动脉收缩，且该收缩受内皮细胞层调节。
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