[组胺及H1受体阻滞剂对细菌内毒素诱导的血小板聚集的影响]
[Effect of histamine and H1-receptor blockaders on bacterial endotoxin-induced thrombocyte aggregation].
作者信息
Shenkman B Z
出版信息
Farmakol Toksikol. 1986 Mar-Apr;49(2):13-5.
PMID:2872081
Abstract
Histamine and dimedrol exerted in vitro inhibitory effects on endotoxin-induced platelet aggregation. When administered at high concentrations pyrilamine potentiated aggregating influence of endotoxin. The experimental results indicate difference in effects of dimedrol and pyrilamine falling into the same group of H1-blockers in relation to induced platelet aggregation.
摘要
组胺和苯海拉明在体外对内毒素诱导的血小板聚集有抑制作用。当以高浓度给药时，吡苄明增强了内毒素的聚集作用。实验结果表明，在诱导血小板聚集方面，苯海拉明和吡苄明虽属于同一组H1受体阻滞剂，但其作用存在差异。
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