乙烷二甲磺酸盐（EDS）对双侧隐睾大鼠睾丸的影响。

The effects of ethane dimethane sulphonate (EDS) on bilaterally cryptorchid rat testes.

作者信息

O'Leary P, Jackson A E, Averill S, de Kretser D M

出版信息

Mol Cell Endocrinol. 1986 May;45(2-3):183-90. doi: 10.1016/0303-7207(86)90146-2.

PMID:2872093

Abstract

A single dose of ethane dimethane sulphonate (EDS) given to adult male rats has a specific destructive effects on Leydig cells, which are removed from the intertubular area by macrophages. This is associated with a decrease in testosterone (T) and a rise in serum FSH and LH for 21-28 days after EDS. Recovery of Leydig cells occurs from connective tissue precursors. This study uses the bilaterally cryptorchid rat to investigate the influence of local factors from the seminiferous tubules on the restoration of Leydig cell morphology and function. Morphometric data of intertubular tissue, hCG binding, serum T, FSH and LH levels all indicate that the Leydig cell population in cryptorchid testes is more rapidly restored from connective tissue cells when compared to the normal situation. The precise mechanism for this faster recovery will require further study.

摘要

给成年雄性大鼠单次注射乙烷二甲磺酸盐（EDS）会对睾丸间质细胞产生特异性破坏作用，这些细胞会被巨噬细胞从曲细精管间区域清除。这与EDS注射后21至28天内睾酮（T）水平降低以及血清促卵泡激素（FSH）和促黄体生成素（LH）水平升高有关。睾丸间质细胞从结缔组织前体细胞开始恢复。本研究采用双侧隐睾大鼠来研究来自曲细精管的局部因素对睾丸间质细胞形态和功能恢复的影响。曲细精管间组织的形态计量学数据、人绒毛膜促性腺激素（hCG）结合情况、血清T、FSH和LH水平均表明，与正常情况相比，隐睾睾丸中的睾丸间质细胞群体从结缔组织细胞恢复得更快。这种更快恢复的确切机制尚需进一步研究。