Youn Young Chul, Jang Jae-Won, Han Su-Hyun, Kim HyeRyoun, Seok Ju-Won, Byun Jun Soo, Park Kwang-Yeol, An Seong Soo A, Chun In Kook, Kim SangYun
Department of Neurology, Chung-Ang University College of Medicine, Seoul.
Department of Neurology, Kangwon National University Hospital.
Clin Interv Aging. 2017 Jun 29;12:1041-1048. doi: 10.2147/CIA.S132884. eCollection 2017.
Early-onset Alzheimer's disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer's disease were absent.
We genotyped , , and in the patients with Alzheimer's disease: 9 patients with EOAD (age <65), 11 with LOAD (age >70) and 8 normal controls (NCs), all of whom had undergone C-labeled Pittsburgh compound B-positron emission tomography imaging.
Patients with EOAD exhibited higher scores and larger cluster sizes, and retained higher levels of Pittsburgh compound B in the bilateral thalamus and in some parts of the globus pallidus (<0.05, false discovery rate).
Distribution of amyloid deposition in EOAD outside the context of genetic mutations topographically showed some differences from that in LOAD.
早发性阿尔茨海默病（EOAD）与晚发性阿尔茨海默病（LOAD）相比，具有不同的病理负担和临床特征。我们研究了发病年龄对无明确阿尔茨海默病相关突变的EOAD患者β淀粉样蛋白负担和分布的影响。
我们对阿尔茨海默病患者进行了 、 、 和 的基因分型：9 例 EOAD 患者（年龄<65 岁）、11 例 LOAD 患者（年龄>70 岁）和 8 例正常对照（NCs），所有患者均接受了 C 标记的匹兹堡化合物 B 正电子发射断层扫描成像。
EOAD 患者表现出更高的 评分和更大的簇大小，并且在双侧丘脑和苍白球的某些部位保留了更高水平的匹兹堡化合物 B（<0.05，错误发现率）。
在无基因突变情况下，EOAD 中淀粉样蛋白沉积的分布在地形上与 LOAD 存在一些差异。
