Alexander P E, Alexander D D
J Clin Psychiatry. 1986 Jun;47(6):301-4.
Office records of 27 private patients who were treated with alprazolam for panic disorders were evaluated by a second psychiatrist. Alprazolam treatment led to a complete remission of panic attacks in 85% of the patients; panics ceased within an average of 6 days, at a mean dose of 2.2 mg/day. In addition, alprazolam was found to bring about a complete absence of phobic avoidance behavior in 21 of the 23 agoraphobic patients in the group. This is the first study to demonstrate the efficacy of medication alone as a treatment for agoraphobia.
第二位精神科医生对27名接受阿普唑仑治疗恐慌症的私人患者的病历进行了评估。阿普唑仑治疗使85%的患者恐慌症完全缓解;恐慌平均在6天内停止,平均剂量为2.2毫克/天。此外,该组23名广场恐惧症患者中有21名患者使用阿普唑仑后完全没有恐惧回避行为。这是第一项证明仅药物治疗广场恐惧症有效的研究。