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[局部复发性直肠癌的当前手术策略]

[Current surgical strategy of locally recurrent rectal cancer].

作者信息

Wang Xin, Jiang Yong

机构信息

Department of General Surgery, Peking University First Hospital, Beijing 100034, China.

出版信息

Zhonghua Wei Chang Wai Ke Za Zhi. 2017 Jul 25;20(7):748-752.

Abstract

The incidence of locally recurrent rectal cancer (LRRC) is less than 10% following treatment for primary rectal cancer, while LRRC usually has serious symptoms and a very low survival rate when lack of treatment. For further efficacy improvement of LRRC operation, recent research topics include preoperative precise evaluation, correct decision, reasonable individual treatment by multidisciplinary collaboration. Surgery remains the only option for potential cure. Studies show R0 resection is the most important prognostic factor. Peking University First Hospital proposes a new classification of LRRC: Pelvic cavity is divided into right pelvic wall, left pelvic wall and posterior sacrococcyx. LRRC is classified as F0 to F3 according to invasion quantity in pelvic wall or sacrococcyx. This classification is more suitable for clinical practice. Though determining the LRRC location by CT, MRI and PET, scientific classification evaluation and correct choice of proper patients using F classification to fix the extent of pelvic wall can effectively elevate the R0 resection rate, and at the same time, can avoid ineffectual high-risk re-operation. This article also investigates the efficacy of comprehensive treatment based on preoperative neoadjuvant therapy, intra-operative radiotherapy and re-radiotherapy, in order to provide the guidance for the institution of reasonable and scientific treatment strategy in clinic.

摘要

原发性直肠癌治疗后局部复发性直肠癌(LRRC)的发生率低于10%,而LRRC若不接受治疗通常会出现严重症状且生存率极低。为进一步提高LRRC手术的疗效,近期的研究课题包括术前精确评估、正确决策、通过多学科协作进行合理的个体化治疗。手术仍然是实现潜在治愈的唯一选择。研究表明,R0切除是最重要的预后因素。北京大学第一医院提出了一种新的LRRC分类方法:将盆腔分为右盆腔壁、左盆腔壁和后骶尾骨。根据LRRC对盆腔壁或骶尾骨的侵犯程度将其分为F0至F3级。这种分类更适用于临床实践。通过CT、MRI和PET确定LRRC的位置,采用F分类法进行科学的分类评估并正确选择合适的患者以确定盆腔壁的范围,可有效提高R0切除率,同时避免无效的高风险再次手术。本文还探讨了基于术前新辅助治疗、术中放疗和再放疗的综合治疗效果,以便为临床制定合理科学的治疗策略提供指导。

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