Chen Shanwen, Wang Pengyuan, Liu Yucun
Department of General Surgery, Peking University First Hospital, Beijing 100034, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2017 Jul 25;20(7):834-840.
As the third confirmed gaseous transmitters, hydrogen sulfide was found to play a vital role in the eternal milieu both physiologically and pathologically. What's intriguing is that, there exists a debate about the role of hydrogen sulfide in the pathogenesis of cancer, especially colorectal cancer. In this manuscript, progress of the effect of low and high dose hydrogen sulfide on the tumorigenesis of colorectal cancer and research on the antitumor new drugs stemmed from the function of hydrogen sulfide is summarized. Recently, the "bell-shape" model of the action of hydrogen sulfide illustrated that hydrogen sulfide was able to promote the progression of tumor in low dose and inhibit the progression of tumor in high dose. Based on these results, both hydrogen sulfide synthesis inhibitors and hydrogen sulfide donors(chimeras with NSAIDs) have been widely studied as potential anti-tumor novel drugs. According to the actual results of present studies, hydrogen sulfide synthesis inhibitors featured by aminooxyacetic acid (AOA) is more promising as a novel kind of drug. The future research based on the relationship between hydrogen sulfide and rectal cancer may bring insights into the development of novel anti-tumor drugs, thus producing tremendous potential clinical value.
作为第三种被证实的气体递质，硫化氢在生理和病理的内环境稳态中都发挥着至关重要的作用。有趣的是，关于硫化氢在癌症尤其是结直肠癌发病机制中的作用存在争议。在本手稿中，总结了低剂量和高剂量硫化氢对结直肠癌肿瘤发生的影响以及源于硫化氢功能的抗肿瘤新药的研究进展。最近，硫化氢作用的“钟形”模型表明，低剂量硫化氢能够促进肿瘤进展，而高剂量硫化氢则抑制肿瘤进展。基于这些结果，硫化氢合成抑制剂和硫化氢供体（与非甾体抗炎药的嵌合体）作为潜在的抗肿瘤新药已得到广泛研究。根据目前研究的实际结果，以氨基氧乙酸（AOA）为特征的硫化氢合成抑制剂作为一种新型药物更具前景。基于硫化氢与直肠癌关系的未来研究可能为新型抗肿瘤药物的开发带来启示，从而产生巨大的潜在临床价值。
