Miller F, Menninger J, Whitcup S M
J Clin Psychopharmacol. 1986 Jun;6(3):176-8.
The frequency and clinical characteristics of lithium- and neuroleptic-mediated neurotoxicity were determined in 10 elderly bipolar patients. When lithium was used alone and therapeutic serum lithium levels were achieved, neurotoxicity did not develop. However, when a neuroleptic was added, neurotoxicity developed in 60% (three of five) of patients and was characterized by delirium, extrapyramidal signs, and cerebellar dysfunction. Neurotoxicity occurred despite the use of neuroleptic dosages that are considered safe and useful when administered in the absence of other psychoactive drugs.
在10例老年双相情感障碍患者中，确定了锂盐和抗精神病药物介导的神经毒性的发生率及临床特征。单独使用锂盐并达到治疗性血清锂水平时，未发生神经毒性。然而，当加用抗精神病药物后，60%（5例中的3例）的患者出现了神经毒性，其特征为谵妄、锥体外系症状和小脑功能障碍。尽管使用的抗精神病药物剂量在不使用其他精神活性药物时被认为是安全有效的，但仍发生了神经毒性。
