Eastham J H, Jeste D V
Department of Psychiatry, University of California, San Diego, USA.
Eur Arch Psychiatry Clin Neurosci. 1997;247(4):209-18. doi: 10.1007/BF02900217.
With increasing longevity, greater numbers of patients with schizophrenia and delusional disorder will be surviving into advanced age. Antipsychotics form the core of the treatment for both of these psychotic disorders. Treatment of elderly patients with antipsychotics is, however, complicated by a much higher risk of adverse effects such as tardive dyskinesia. More is known about treating patients with schizophrenia than those with delusional disorder. The introduction of newer atypical antipsychotics may herald a new era in the pharmacotherapy of elderly psychotic patients. Nonetheless, judicious dosing is essential in the geriatric population. We discuss the benefits and limitations of the main forms of treatment.
随着寿命的延长，越来越多的精神分裂症和妄想障碍患者将存活至高龄。抗精神病药物是这两种精神障碍治疗的核心。然而，老年患者使用抗精神病药物治疗时，迟发性运动障碍等不良反应的风险要高得多，这使得治疗变得复杂。相对于妄想障碍患者，我们对精神分裂症患者的治疗了解得更多。新型非典型抗精神病药物的引入可能预示着老年精神病患者药物治疗的新时代。尽管如此，在老年人群中谨慎给药至关重要。我们讨论了主要治疗方式的益处和局限性。
