Lang Caroline, Quenan Sandrine
Service de dermatologie et vénéréologie, HUG, 1211 Genève 14.
Rev Med Suisse. 2017 Mar 29;13(556):678-683.
Sweet's syndrome is a rare neutrophilic dermatosis. Typically, patients present with a sudden onset of tender erythematous skin lesions (papules, nodules, and plaques), of asymetrical distribution, located preferentially on the superior limbs, face and neck, associated whith high fever and neutrophilia. Histologicaly, there is a diffuse infiltrate of neutrophils located in the dermis. Most of the time idiopathic, it may be associated with a respiratory or gastro-intestinal infection, with inflammatory bowel disease, pregnancy and vaccination. A drug-induced form and a malignancy-associated form have been described. Based on illustrations and two clinical cases, we wish to focus on the diagnostic strategy and the management of this disease.
斯威特综合征是一种罕见的嗜中性皮病。通常,患者会突然出现压痛性红斑皮肤病变(丘疹、结节和斑块),分布不对称,主要位于上肢、面部和颈部,伴有高热和嗜中性粒细胞增多。组织学上,真皮中有弥漫性嗜中性粒细胞浸润。大多数情况下为特发性,可能与呼吸道或胃肠道感染、炎症性肠病、妊娠和疫苗接种有关。已经描述了药物诱导型和恶性肿瘤相关型。基于插图和两个临床病例,我们希望聚焦于该疾病的诊断策略和治疗。