Berlant J L
J Clin Psychopharmacol. 1986 Jun;6(3):180-4.
This retrospective review of the naturalistic use of reserpine in combination with neuroleptics for symptoms refractory to neuroleptics and lithium demonstrated a moderate to dramatic response rate in 50% of 36 chronically disabled psychotic patients. Observed improvement was in marked contrast to the baseline pattern of chronically persistent psychotic symptoms and poor functioning in these patients. Female patients and patients with schizoaffective or bipolar diagnoses responded best to treatment. Reserpine may be an underutilized adjunctive treatment for refractory psychotic states, and further investigation into its clinical applications is warranted.
这项对利血平与抗精神病药物联合用于对抗精神病药物和锂剂治疗无效症状的自然主义使用情况的回顾性研究表明，在36例慢性残疾精神病患者中，50%的患者有中度到显著的反应率。观察到的改善与这些患者慢性持续性精神病症状和功能不良的基线模式形成鲜明对比。女性患者以及精神分裂情感性障碍或双相诊断的患者对治疗反应最佳。利血平可能是一种未得到充分利用的难治性精神病状态辅助治疗药物，有必要对其临床应用进行进一步研究。
