Hopp Elizabeth E, Cossette Stephanie M, Kumar Suresh N, Eastwood Daniel, Ramchandran Ramani, Bishop Erin
a Department of Obstetrics and Gynecology , Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
b Department of Pediatrics, Children's Research Institute, Division of Neonatology , Medical College of Wisconsin , Milwaukee , Wisconsin , USA.
Cancer Invest. 2017 Aug 9;35(7):456-462. doi: 10.1080/07357907.2017.1337781. Epub 2017 Jul 19.
Sucrose non-fermenting related kinase (SNRK) is a serine/threonine kinase known to regulate cellular metabolism and adipocyte inflammation. Since alterations in adipocyte metabolism play a role in ovarian cancer metastasis, we investigated the expression of SNRK in benign and malignant human ovarian tissue using immunohistochemistry and qPCR. The number of SNRK positive (+) nuclei is increased in malignant tissue compared to benign tissue (21.03% versus 14.90%, p < .0431). The most strongly stained malignant SNRK+ nuclei were stage 1 compared to stage 2-4 disease. Differential expression of SNRK in early versus late stage disease suggests specific roles for SNRK in ovarian cancer metastasis.
蔗糖非发酵相关激酶（SNRK）是一种丝氨酸/苏氨酸激酶，已知其可调节细胞代谢和脂肪细胞炎症。由于脂肪细胞代谢的改变在卵巢癌转移中起作用，我们使用免疫组织化学和定量聚合酶链反应（qPCR）研究了SNRK在人卵巢良性和恶性组织中的表达。与良性组织相比，恶性组织中SNRK阳性（+）细胞核的数量增加（21.03%对14.90%，p < 0.0431）。与2-4期疾病相比，1期恶性SNRK+细胞核的染色最强。SNRK在疾病早期和晚期的差异表达表明其在卵巢癌转移中具有特定作用。
