Goyal Neera K, DeFranco Emily, Kamath-Rayne Beena D, Beck Andrew F, Hall Eric S
Department of Pediatrics, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA.
Division of General Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE.
Paediatr Perinat Epidemiol. 2017 Sep;31(5):385-391. doi: 10.1111/ppe.12376. Epub 2017 Jul 19.
Infant mortality rate (IMR), or number of infant deaths per 1000 livebirths, varies widely across the US While fetal deaths are not included in this measure, reported infant deaths do include those delivered at previable gestations, or ≤20 weeks gestation. Variation in reporting of these events may have a significant impact on IMR estimates.
This retrospective analysis used US National Center for Health Statistics 2007-2013 data from 2391 US counties. Counties were categorised by US region, demographic characteristics, and state-level fetal death reporting requirements. County percentage of fetal deaths among all 17-20 week fetal and infant deaths was evaluated using multivariable linear regression. County-level characteristics were then included in multivariable linear regression to determine the associated change in county IMR.
County percentage of deaths at 17-20 weeks reported as fetal ranged from 0% to 100% (mean 63.7%). Every 1 point increase in this percentage was associated with a 0.02 point decrease in county IMR (95% confidence interval (CI) 0.02, 0.03). When county IMRs were recalculated holding the percentage of fetal vs. infant deaths at 17-20 weeks constant at 63.7%, results suggest that the predicted gap in county IMR between Northeast and Midwest regions would narrow by 0.45 points.
Variable reporting of previable fetal and infant deaths may compromise the validity of county IMR comparisons. Improved consistency and accuracy of fetal and infant death reporting is warranted.
婴儿死亡率(IMR),即每1000例活产婴儿中的婴儿死亡数,在美国各地差异很大。虽然死胎不包括在这一指标中,但报告的婴儿死亡确实包括那些在可存活孕周之前分娩的婴儿,即妊娠≤20周的婴儿。这些事件报告的差异可能对IMR估计产生重大影响。
这项回顾性分析使用了美国国家卫生统计中心2007 - 2013年来自2391个美国县的数据。根据美国地区、人口特征和州级死胎报告要求对各县进行分类。使用多变量线性回归评估所有17 - 20周死胎和婴儿死亡中县死胎的百分比。然后将县级特征纳入多变量线性回归,以确定县IMR的相关变化。
报告为死胎的17 - 20周死亡的县百分比范围为0%至100%(平均63.7%)。该百分比每增加1个百分点,县IMR就会降低0.02个百分点(95%置信区间(CI)0.02,0.03)。当将17 - 20周死胎与婴儿死亡的百分比保持在63.7%不变重新计算县IMR时,结果表明,东北部和中西部地区县IMR之间的预测差距将缩小0.45个百分点。
可存活前死胎和婴儿死亡报告的差异可能会损害县IMR比较的有效性。有必要提高死胎和婴儿死亡报告的一致性和准确性。