细胞程序性坏死：（最后的）泡泡里的信息。
Necroptosis: (Last) Message in a Bubble.
机构信息
Molecular Signaling and Cell Death Unit, VIB Inflammation Research Center, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Methusalem Program, Ghent University, Ghent, Belgium.
Molecular Signaling and Cell Death Unit, VIB Inflammation Research Center, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Unité de Glycobiologie Structurale et Fonctionnelle, CNRS-UMR 8576, Université Lille1, Villeneuve d'Ascq, France.
出版信息
Immunity. 2017 Jul 18;47(1):1-3. doi: 10.1016/j.immuni.2017.07.002.
RIPK3 kinase-mediated phosphorylation of MLKL pseudokinase is the execution event of necroptosis. Two independent reports-in Immunity (Yoon et al., 2017) and Cell (Gong et al., 2017)-reveal that MLKL affects homeostatic membrane trafficking and necroptosis-enhanced bubble formation involving interaction with the ESCRT machinery.
RIPK3 激酶介导的 MLKL 假激酶的磷酸化是坏死性细胞死亡的执行事件。两篇独立的报道——《免疫》（Yoon 等人，2017 年）和《细胞》（Gong 等人，2017 年）——揭示了 MLKL 影响着稳态膜运输，以及涉及与 ESCRT 机制相互作用的坏死性细胞死亡增强的泡形成。
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