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CD300f：IL-5 串扰抑制脂肪组织嗜酸性粒细胞归巢和随后的 IL-4 产生。

CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production.

机构信息

Department of Clinical Microbiology and Immunology, The Sackler School of Medicine, Tel-Aviv University, Ramat Aviv, 69978, Israel.

Bioinformatics Unit, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 64239, Israel.

出版信息

Sci Rep. 2017 Jul 19;7(1):5922. doi: 10.1038/s41598-017-06397-4.

DOI:10.1038/s41598-017-06397-4
PMID:28725048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5517555/
Abstract

Eosinophils and their associated cytokines IL-4 and IL-5 are emerging as central orchestrators of the immune-metabolic axis. Herein, we demonstrate that cross-talk between the Ig-superfamily receptor CD300f and IL-5 is a key checkpoint that modifies the ability of eosinophils to regulate metabolic outcomes. Generation of Il5 /Cd300f mice revealed marked and distinct increases in eosinophil levels and their production of IL-4 in the white and brown adipose tissues. Consequently, Il5 /Cd300f mice had increased alternatively activated macrophage accumulation in the adipose tissue. Cd300f mice displayed age-related accumulation of eosinophils and macrophages in the adipose tissue and decreased adipose tissue weight, which was associated with decreased diet-induced weight gain and insulin resistance. Notably, Il5 /CD300f were protected from diet-induced weight gain and glucose intolerance. These findings highlight the cross-talk between IL-5 receptor and CD300f as a novel pathway regulating adipose tissue eosinophils and offer new entry points for therapeutic intervention for obesity and its complications.

摘要

嗜酸性粒细胞及其相关细胞因子 IL-4 和 IL-5 正在成为免疫代谢轴的核心调节者。在此，我们证明 Ig 超家族受体 CD300f 和 IL-5 之间的串扰是一个关键的检查点，它改变了嗜酸性粒细胞调节代谢结果的能力。生成 Il5 / Cd300f 小鼠显示出嗜酸性粒细胞水平的显著增加，以及它们在白色和棕色脂肪组织中产生的 IL-4。因此，Il5 / Cd300f 小鼠在脂肪组织中表现出交替激活的巨噬细胞积累增加。Cd300f 小鼠表现出脂肪组织中嗜酸性粒细胞和巨噬细胞的年龄相关性积累以及脂肪组织重量的减少，这与饮食诱导的体重增加和胰岛素抵抗减少有关。值得注意的是，Il5 / CD300f 免受饮食诱导的体重增加和葡萄糖不耐受的影响。这些发现强调了 IL-5 受体和 CD300f 之间的串扰作为调节脂肪组织嗜酸性粒细胞的新途径，并为肥胖及其并发症的治疗干预提供了新的切入点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a76f/5517555/fb1460d0d0b9/41598_2017_6397_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a76f/5517555/01ee937956b5/41598_2017_6397_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a76f/5517555/a085f06d3eae/41598_2017_6397_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a76f/5517555/fb1460d0d0b9/41598_2017_6397_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a76f/5517555/01ee937956b5/41598_2017_6397_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a76f/5517555/bb9e10250760/41598_2017_6397_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a76f/5517555/d112a3fc06d4/41598_2017_6397_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a76f/5517555/26461dfc01db/41598_2017_6397_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a76f/5517555/61cbc335be38/41598_2017_6397_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a76f/5517555/a085f06d3eae/41598_2017_6397_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a76f/5517555/fb1460d0d0b9/41598_2017_6397_Fig7_HTML.jpg

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本文引用的文献

1
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Mucosal Immunol. 2017 Jan;10(1):172-183. doi: 10.1038/mi.2016.37. Epub 2016 Apr 27.
2
Humanized Anti-IL-5 Antibody Therapy.人源化抗白细胞介素-5抗体疗法
Cell. 2016 Apr 21;165(3):509. doi: 10.1016/j.cell.2016.04.020.
3
Regulation of metabolism by the innate immune system.先天免疫系统对代谢的调节。
雷贝拉唑治疗通过调节免疫细胞和脂肪细胞改善肥胖表型。
PLoS One. 2022 Dec 27;17(12):e0277692. doi: 10.1371/journal.pone.0277692. eCollection 2022.
4
Differential regulation of Type 1 and Type 2 mouse eosinophil activation by apoptotic cells.凋亡细胞对 1 型和 2 型鼠嗜酸性粒细胞激活的差异调节。
Front Immunol. 2022 Oct 31;13:1041660. doi: 10.3389/fimmu.2022.1041660. eCollection 2022.
5
Immune Cells in Thermogenic Adipose Depots: The Essential but Complex Relationship.产热脂肪组织中的免疫细胞：必要但复杂的关系。
Front Endocrinol (Lausanne). 2022 Mar 14;13:839360. doi: 10.3389/fendo.2022.839360. eCollection 2022.
6
Bidirectional crosstalk between eosinophils and esophageal epithelial cells regulates inflammatory and remodeling processes.嗜酸性粒细胞与食管上皮细胞间的双向相互作用调节炎症和重塑过程。
Mucosal Immunol. 2021 Sep;14(5):1133-1143. doi: 10.1038/s41385-021-00400-y. Epub 2021 May 10.
7
Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies.嗜酸性粒细胞敲除人类：通过靶向嗜酸性粒细胞的生物治疗揭示嗜酸性粒细胞的作用。
Annu Rev Immunol. 2021 Apr 26;39:719-757. doi: 10.1146/annurev-immunol-093019-125918. Epub 2021 Mar 1.
8
The Expression and Function of CD300 Molecules in the Main Players of Allergic Responses: Mast Cells, Basophils and Eosinophils.CD300 分子在过敏反应主要参与者中的表达和功能：肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞。
Int J Mol Sci. 2020 Apr 30;21(9):3173. doi: 10.3390/ijms21093173.
9
Contributions of Eosinophils to Human Health and Disease.嗜酸性粒细胞对人类健康和疾病的贡献。
Annu Rev Pathol. 2020 Jan 24;15:179-209. doi: 10.1146/annurev-pathmechdis-012419-032756.
10
The Role of NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology.NADPH 氧化酶在肥胖和代谢综合征发病机制中的作用：个体同工型和细胞生物学的贡献。
Antioxid Redox Signal. 2019 Oct 1;31(10):687-709. doi: 10.1089/ars.2018.7674.
Nat Rev Endocrinol. 2016 Jan;12(1):15-28. doi: 10.1038/nrendo.2015.189. Epub 2015 Nov 10.
4
A protective role for IL-13 receptor α 1 in bleomycin-induced pulmonary injury and repair.白细胞介素-13受体α1在博来霉素诱导的肺损伤及修复中的保护作用。
Mucosal Immunol. 2016 Jan;9(1):240-53. doi: 10.1038/mi.2015.56. Epub 2015 Jul 8.
5
CD300f associates with IL-4 receptor α and amplifies IL-4-induced immune cell responses.CD300f与白细胞介素-4受体α结合，并增强白细胞介素-4诱导的免疫细胞反应。
Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8708-13. doi: 10.1073/pnas.1507625112. Epub 2015 Jun 29.
6
Deletion of Stat3 enhances myeloid cell expansion and increases the severity of myeloproliferative neoplasms in Jak2V617F knock-in mice.在Jak2V617F基因敲入小鼠中，Stat3基因的缺失增强了髓系细胞的扩增，并增加了骨髓增殖性肿瘤的严重程度。
Leukemia. 2015 Oct;29(10):2050-61. doi: 10.1038/leu.2015.116. Epub 2015 May 18.
7
Immune regulation of metabolic homeostasis in health and disease.健康与疾病状态下代谢稳态的免疫调节
Cell. 2015 Mar 26;161(1):146-160. doi: 10.1016/j.cell.2015.02.022.
8
Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials.瑞利珠单抗治疗血嗜酸性粒细胞计数升高的哮喘控制不佳：两项多中心、平行、双盲、随机、安慰剂对照、3 期临床试验结果。
Lancet Respir Med. 2015 May;3(5):355-66. doi: 10.1016/S2213-2600(15)00042-9. Epub 2015 Feb 23.
9
Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation.神经酰胺-CD300f结合通过抑制ATP介导的肥大细胞活化来抑制实验性结肠炎。
Gut. 2016 May;65(5):777-87. doi: 10.1136/gutjnl-2014-308900. Epub 2015 Feb 11.
10
Activated type 2 innate lymphoid cells regulate beige fat biogenesis.活化的2型天然淋巴细胞调节米色脂肪生成。
Cell. 2015 Jan 15;160(1-2):74-87. doi: 10.1016/j.cell.2014.12.011. Epub 2014 Dec 24.