1例由甲巯咪唑引起的重症结节性红斑。

A case of severe erythema nodosum induced by methimazole.

作者信息

Emre Selma, Ozdemir Didem, Orhun Sibel, Kalkan Goknur, Sener Sertac

机构信息

Yildirim Beyazit University, Ataturk Training and Research Hospital, Dermatology Clinic, Ankara, Turkey.

Yildirim Beyazit University, Ataturk Training and Research Hospital, Endocrinology Clinic, Ankara, Turkey.

出版信息

Saudi Pharm J. 2017 Jul;25(5):813-815. doi: 10.1016/j.jsps.2016.11.003. Epub 2016 Nov 12.

DOI:10.1016/j.jsps.2016.11.003

PMID:28725155

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5506710/

Abstract

Erythema nodosum (EN), is the most common variant of septal panniculitis and is possibly a delayed hypersensitivity reaction triggered by a wide range of antigenic stimuli. Hypersensitivity reactions due to medications have been recognized as a cause of 3-10% of EN cases. Case reports of EN associated with the anti-thyroid drugs are quite rarely reported in the literature even if there is a common use of anti-thyroid drugs. We report an EN case due to methimazole. The complaints of patients arose immediately fifteen days after the beginning of methimazole treatment. To the best of our knowledge, this case report is the first of an erythema nodosum induced by methimazole.

摘要

结节性红斑（EN）是间隔性脂膜炎最常见的类型，可能是由多种抗原刺激引发的迟发型超敏反应。药物引起的超敏反应已被认为是3%至10%的结节性红斑病例的病因。尽管抗甲状腺药物应用广泛，但与抗甲状腺药物相关的结节性红斑病例报告在文献中却鲜有报道。我们报告一例因甲巯咪唑引起的结节性红斑病例。患者的症状在甲巯咪唑治疗开始后的第15天立即出现。据我们所知，本病例报告是首例由甲巯咪唑诱发的结节性红斑。