Curley Louise E, Kennedy Julia, Hinton Jordan, Mirjalili Ali, Svirskis Darren
School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, 1142 New Zealand.
Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
J Pharm Policy Pract. 2017 Jul 17;10:22. doi: 10.1186/s40545-017-0110-1. eCollection 2017.
Despite pharmaceutical sciences being a core component of pharmacy curricula, few published studies have focussed on innovative methodologies to teach the content. This commentary identifies imaging techniques which can visualise oral dosage forms in-vivo and observe formulation disintegration in order to achieve a better understanding of in-vivo performance. Images formed through these techniques can provide students with a deeper appreciation of the fate of oral formulations in the body compared to standard disintegration and dissolution testing, which is conducted in-vitro. Such images which represent the in-vivo setting can be used in teaching to give context to both theory and experimental work, thereby increasing student understanding and enabling teaching of pharmaceutical sciences supporting students to correlate in-vitro and in-vivo processes.
尽管药物科学是药学课程的核心组成部分,但很少有已发表的研究专注于讲授该内容的创新方法。本评论确定了能够在体内可视化口服剂型并观察制剂崩解的成像技术,以便更好地理解体内性能。与在体外进行的标准崩解和溶出度测试相比,通过这些技术形成的图像可以让学生更深入地了解口服制剂在体内的命运。这些代表体内情况的图像可用于教学,为理论和实验工作提供背景,从而增强学生的理解,并有助于讲授药物科学,支持学生关联体外和体内过程。