MicroRNA in hormonal mechanisms of regulation of NK cell function.

作者信息

Shirshev S V, Nekrasova I V, Gorbunova O L, Orlova E G, Maslennikova I L

机构信息

Institute of Ecology and Genetics of Microorganisms, Ural Department, Russian Academy of Science, Perm, 614081, Russia.

出版信息

Dokl Biochem Biophys. 2017 May;474(1):168-172. doi: 10.1134/S160767291703005X. Epub 2017 Jul 20.

We investigated the effect of human chorionic gonadotropin, estriol, leptin, ghrelin, and kisspeptin on the microRNA expression in separated NK cells. All of these hormones are able to effectively modulate the expression of microRNAs both stimulating and suppressing the cytotoxic potential of NK cells and thereby indirectly regulate the functions of these lymphocytes.