Yamamura T, Takahashi T, Kusunoki M, Kantoh M, Ishikawa Y, Utsunomiya J
Neurosci Lett. 1986 Apr 11;65(2):167-70. doi: 10.1016/0304-3940(86)90298-3.
Cholecystokinin-octapeptide (CCK-OP) produced a contractile response in isolated guinea pig gallbladder; the response consisted of scopolamine-sensitive and scopolamine-insensitive components, neither of which were affected by tetrodotoxin or hexamethonium. In the presence of tetrodotoxin, CCK-OP evoked [3H]acetylcholine (ACh) release from strips of gallbladder in a concentration-dependent manner. These results suggest that CCK-OP acts at two sites in the guinea pig gallbladder, viz. the smooth muscle cell and the postganglionic cholinergic nerve terminal.
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