三磷酸腺苷用于嗜铬细胞瘤术中血压控制

Intraoperative blood pressure control by ATP in pheochromocytoma.

作者信息

Aso Y, Tajima A, Suzuki K, Ohmi Y, Kanbayashi T, Mitsuhashi T, Ikeda K

出版信息

Urology. 1986 Jun;27(6):512-20. doi: 10.1016/0090-4295(86)90330-4.

Abstract

Three cases of pheochromocytoma which were successfully treated with the use of adenosine triphosphate (ATP) during the operation are reported. The mechanism of the hypotensive effect of ATP has been proved due to the antagonizing action of the agent to the vasoconstriction by noradrenaline and/or sympathetic nerve stimulation. In these 3 cases, ATP has been safely and effectively applied to control blood pressure in pheochromocytoma. ATP could be used as the first-choice drug to keep the circulatory state stable during surgery for pheochromocytoma.

摘要

本文报告了3例嗜铬细胞瘤患者，术中使用三磷酸腺苷（ATP）成功进行治疗。ATP降压作用的机制已得到证实，这是由于该药物对去甲肾上腺素和/或交感神经刺激引起的血管收缩具有拮抗作用。在这3例患者中，ATP已被安全有效地用于控制嗜铬细胞瘤患者的血压。ATP可作为嗜铬细胞瘤手术期间维持循环状态稳定的首选药物。