Luk Jeremy W, Liang Tiebing, Wall Tamara L
Department of Psychiatry, University of California, San Diego, San Diego, California.
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
J Stud Alcohol Drugs. 2017 Jul;78(4):531-539. doi: 10.15288/jsad.2017.78.531.
Among northeast Asians, the variant aldehyde dehydrogenase allele, ALDH22 (rs671, A/G, minor/major), has been inversely associated with alcohol dependence. The strength of the associations between ALDH22 and drinking behaviors depends on the developmental stage, the phenotype studied, and other moderating variables. This study examined ALDH2 gene status as a moderator of the associations between parental drinking, peer drinking, and acculturation with alcohol use among 222 Chinese American and Korean American college freshmen.
Negative binomial regressions were used to test the main and interactive effects of ALDH2 with contextual factors on alcohol frequency (drinking days) and quantity (drinks per drinking day) in the past 3 months.
ALDH22 was associated with more subjective flushing symptoms and longer length of flushing but was unrelated to both alcohol frequency and quantity. Peer drinking was positively associated with both alcohol frequency and quantity, but neither was moderated by ALDH2. We observed a nonsignificant trend for the interaction between parental drinking and ALDH2 on alcohol frequency, where parental drinking was positively associated with alcohol frequency only among participants with ALDH22. We found a significant interaction between acculturation and ALDH2 on alcohol frequency, where acculturation was positively associated with alcohol frequency only among those with ALDH2*2. Exploratory analyses stratified by Asian ethnic subgroup indicated that this interaction was driven primarily by the Korean subsample.
Parental drinking and acculturation may facilitate more frequent drinking among those who have more intense reactions to alcohol (i.e., those with ALDH2*2) during the transition from high school to college.
在东北亚人群中，醛脱氢酶变异等位基因ALDH22（rs671，A/G，次要/主要）与酒精依赖呈负相关。ALDH22与饮酒行为之间关联的强度取决于发育阶段、所研究的表型以及其他调节变量。本研究调查了222名华裔美国人和韩裔美国大学新生中，ALDH2基因状态作为父母饮酒、同伴饮酒以及文化适应与酒精使用之间关联的调节因素。
采用负二项回归来检验ALDH2与背景因素对过去3个月内饮酒频率（饮酒天数）和饮酒量（每次饮酒日的饮酒量）的主效应和交互效应。
ALDH22与更明显的主观脸红症状和更长的脸红持续时间相关，但与饮酒频率和饮酒量均无关。同伴饮酒与饮酒频率和饮酒量均呈正相关，但两者均不受ALDH2调节。我们观察到父母饮酒与ALDH2在饮酒频率上的交互作用有不显著的趋势，即仅在携带ALDH22的参与者中，父母饮酒与饮酒频率呈正相关。我们发现文化适应与ALDH2在饮酒频率上有显著的交互作用，即仅在携带ALDH2*2的人群中，文化适应与饮酒频率呈正相关。按亚洲种族亚组分层的探索性分析表明，这种交互作用主要由韩国子样本驱动。
在从高中到大学的过渡阶段，父母饮酒和文化适应可能会促使对酒精反应更强烈的人（即携带ALDH2*2的人）更频繁地饮酒。
