Schley J
Arzneimittelforschung. 1986 Apr;36(4):635-7.
An ethanolic solution of perazine (Taxilan), degraded by photooxidation, was examined by HPLC and mass-spectroscopy. Identical degradation and oxidation products were found in vitro as reported to exist in vivo with the exception of perazine-N-oxide and 3-OH-perazine. The formation of the latter two metabolites seems to be bound to the cytochrome P-450 system. A direct, oxygen dependent formation of some metabolites is, however, suggested. Side-effects of phenothiazines such as contact allergies might be related to the formation of radicals or particular oxidation products.
对经光氧化降解的哌嗪（泰西兰）乙醇溶液进行了高效液相色谱法（HPLC）和质谱分析。除了哌嗪 - N - 氧化物和3 - 羟基哌嗪外，体外发现的降解产物和氧化产物与体内报道存在的产物相同。后两种代谢产物的形成似乎与细胞色素P - 450系统有关。然而，提示某些代谢产物存在直接的、依赖氧气的形成过程。吩噻嗪类药物的副作用如接触性过敏可能与自由基或特定氧化产物的形成有关。
