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可替代自费疫苗接种与扩大免疫规划完成情况之间的关系:中国福建的一项横断面研究

Relationship between receipt of substitutable for-fee vaccines and completion of the expanded programme on immunisation: a cross-sectional study in Fujian, China.

作者信息

Wu Jiang-Nan, Li Da-Jin, Zhou Yong, Du Mei-Rong, Piao Hai-Lan

机构信息

Department of Clinical Epidemiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Department of Expanded Programme on Immunization, Fujian Provincial Center for Disease Control and Prevention, Fuzhou, China.

出版信息

BMJ Open. 2017 Jul 20;7(7):e015666. doi: 10.1136/bmjopen-2016-015666.

Abstract

OBJECTIVE

The aim of this study was to evaluate the relationship between receipt of the substitutable-for-fee vaccines (SFV) and completion of the expanded programme on immunisation (EPI).

DESIGN AND SETTINGS

A cross-sectional study was conducted in Fujian province, China.

PARTICIPANTS

Children who were born from 1 September 2009 to 31 August 2011, and who had been residing in the township for at least 3 months, were randomly recruited from 34 townships.

MAIN OUTCOMES MEASURES

Outcomes were completion rate of the EPI and coverage rate of the SFV.

RESULTS

The study included 1428 children, of whom 1350 (94.5%) finished the EPI and 282 (19.7%) received at least one dose of the SFV. Administration of the SFV was associated with an increased likelihood of completing the EPI (OR=3.2, 95% CI 1.3 to 7.6 in the total sample and OR=4.0, 95% CI 1.7 to 9.6 in the subsample of children in regions with the SFV accessibility). The impact of the SFV administration on completion of the EPI was larger among children whose parents have junior school education or less (97.8% and 97.9% vs 92.5% and 91.9%, both p<0.001) and among those with a timely hepatitis B vaccine first dose (98.5% vs 94.0%, p<0.001).

CONCLUSIONS

Receipt of SFV is associated with increased likelihood of completion of the EPI in Fujian, China.

摘要

目的

本研究旨在评估可替代自费疫苗(SFV)的接种与扩大免疫规划(EPI)完成情况之间的关系。

设计与背景

在中国福建省开展了一项横断面研究。

参与者

从34个乡镇中随机招募了2009年9月1日至2011年8月31日出生、且在该乡镇居住至少3个月的儿童。

主要观察指标

观察指标为EPI的完成率和SFV的覆盖率。

结果

该研究纳入了1428名儿童,其中1350名(94.5%)完成了EPI,282名(19.7%)接种了至少一剂SFV。接种SFV与完成EPI的可能性增加相关(总样本中OR=3.2,95%CI为1.3至7.6;在可获得SFV的地区,儿童子样本中OR=4.0,95%CI为1.7至9.6)。在父母受初中及以下教育的儿童中(分别为97.8%和97.9%,对比92.5%和91.9%,均p<0.001)以及及时接种首剂乙肝疫苗的儿童中(98.5%对比94.0%,p<0.001),接种SFV对完成EPI的影响更大。

结论

在中国福建,接种SFV与完成EPI的可能性增加相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1de2/5642657/99ef96aad999/bmjopen-2016-015666f01.jpg

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