獐牙菜苦甙元从獐牙菜属植物中分离得到。

Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus.

机构信息

School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, P.R. China.

Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, Sichuan, P.R. China.

出版信息

Sci Rep. 2017 Jul 20;7(1):6063. doi: 10.1038/s41598-017-05372-3.

DOI:10.1038/s41598-017-05372-3

PMID:28729705

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5519776/

Abstract

Extensive phytochemical investigation on the whole herbs of Delphinium anthriscifolium var. majus led to the identification of fourteen diterpenoid alkaloids, including three new C-diterpenoid alkaloids (anthriscifolsines A-C, 1-3), six new C-diterpenoid alkaloids (anthriscifolrines A-F, 4-9), and five know compounds (10-14). Among them, anthriscifolsine A represents a novel C-diterpenoid alkaloid characterized by a seco C-ring. The structures of the isolated compounds were elucidated by extensive spectroscopic methods, including HR-ESI-MS, X-ray, and 1D and 2D NMR experiments. Bioactivity of compounds 3-6 was evaluated for their cytotoxicity against the MCF-7, HepG2 and H460 cancer cell lines.

摘要

对大花翠雀全草进行了广泛的植物化学研究，从中鉴定出 14 种二萜生物碱，包括 3 种新的 C-二萜生物碱（anthriscifolsines A-C，1-3）、6 种新的 C-二萜生物碱（anthriscifolrines A-F，4-9）和 5 种已知化合物（10-14）。其中，anthriscifolsine A 代表了一种新型的 C-二萜生物碱，其特征为 sec C-环。通过 HR-ESI-MS、X 射线和 1D 和 2D NMR 实验等广泛的光谱方法阐明了分离化合物的结构。对化合物 3-6 的生物活性进行了评估，以评估它们对 MCF-7、HepG2 和 H460 癌细胞系的细胞毒性。